Natural killer (NK) cells have crucial roles in the innate immunosurveillance of cancer and
viral infections. They are 'first responders' that can spontaneously recognize abnormal cells …

Natural killer (NK) cells can swiftly kill multiple adjacent cells if these show surface markers
associated with oncogenic transformation. This property, which is unique among immune …

Immuno-oncology is an emerging field that has revolutionized cancer treatment. Most
immunomodulatory strategies focus on enhancing T cell responses, but there has been a …

Acute myeloid leukemia (AML) remains a therapeutic challenge, and a paucity of tumor-
specific targets has significantly hampered the development of effective immune-based …

Chimeric antigen receptors (CARs) have been used to redirect the specificity of autologous
T cells against leukemia and lymphoma with promising clinical results. Extending this …

Cells of the innate immunity play an important role in tumor immunotherapy. Thus, NK cells
can control tumor growth and metastatic spread. Thanks to their strong cytolytic activity …

Natural killer (NK) cells are an emerging cellular immunotherapy for patients with acute
myeloid leukemia (AML); however, the best approach to maximize NK cell antileukemia …

Allogeneic hematopoietic cell transplantation involves consideration of both donor and
recipient characteristics to guide the selection of a suitable graft. Sufficient high-resolution …

A key mechanism of tumor resistance to immune cells is mediated by expression of peptide-
loaded HLA class I molecule (HLA-E) in tumor cells, which suppresses NK cell activity via …

New therapies for patients with hematologic malignancies who relapse after allogeneic
hematopoietic cell transplantation (allo-HCT) are needed. Interleukin 15 (IL-15) is a cytokine …