[HTML][HTML] Enabling a circular economy for chemicals in plastics

N Aurisano, R Weber, P Fantke - Current Opinion in Green and Sustainable …, 2021 - Elsevier
Enabling a circular economy for plastics in Europe and beyond is an ambitious goal. In order
to reach a fully closed loop, numerous challenges and knowledge gaps need to be …

[HTML][HTML] Quantitative non-targeted analysis: bridging the gap between contaminant discovery and risk characterization

JP McCord, LC Groff II, JR Sobus - Environment international, 2022 - Elsevier
Chemical risk assessments follow a long-standing paradigm that integrates hazard, dose–
response, and exposure information to facilitate quantitative risk characterization. Targeted …

Uncovering global-scale risks from commercial chemicals in air

Q Liu, L Li, X Zhang, A Saini, W Li, H Hung, C Hao, K Li… - Nature, 2021 - nature.com
Commercial chemicals are used extensively across urban centres worldwide, posing a
potential exposure risk to 4.2 billion people. Harmful chemicals are often assessed on the …

The next generation blueprint of computational toxicology at the US Environmental Protection Agency

RS Thomas, T Bahadori, TJ Buckley… - Toxicological …, 2019 - academic.oup.com
Abstract The US Environmental Protection Agency (EPA) is faced with the challenge of
efficiently and credibly evaluating chemical safety often with limited or no available toxicity …

Utility of In Vitro Bioactivity as a Lower Bound Estimate of In Vivo Adverse Effect Levels and in Risk-Based Prioritization

K Paul Friedman, M Gagne, LH Loo… - Toxicological …, 2020 - academic.oup.com
Use of high-throughput, in vitro bioactivity data in setting a point-of-departure (POD) has the
potential to accelerate the pace of human health safety evaluation by informing screening …

Exposure and toxicity characterization of chemical emissions and chemicals in products: global recommendations and implementation in USEtox

P Fantke, WA Chiu, L Aylward, R Judson… - The international journal …, 2021 - Springer
Purpose Reducing chemical pressure on human and environmental health is an integral
part of the global sustainability agenda. Guidelines for deriving globally applicable, life cycle …

Criteria pollutant impacts of volatile chemical products informed by near-field modelling

M Qin, BN Murphy, KK Isaacs, BC McDonald, Q Lu… - Nature …, 2021 - nature.com
Consumer, industrial and commercial product use is a source of exposure to potentially
hazardous chemicals. In addition, cleaning agents, personal care products, coatings and …

Development of a roadmap for action on new approach methodologies in risk assessment

SE Escher, F Partosch, S Konzok… - EFSA Supporting …, 2022 - Wiley Online Library
While whole animal studies have their place in risk assessment of food and feed
components, it is thought that more modern approaches such as human focused new …

[HTML][HTML] Chemicals of concern in building materials: a high-throughput screening

L Huang, P Fantke, A Ritscher, O Jolliet - Journal of Hazardous Materials, 2022 - Elsevier
Chemicals used in building materials can be a major passive emission source indoors,
associated with the deterioration of indoor environmental quality. This study aims to screen …

The chemical landscape of high-throughput new approach methodologies for exposure

KK Isaacs, P Egeghy, KL Dionisio, KA Phillips… - Journal of exposure …, 2022 - nature.com
The rapid characterization of risk to humans and ecosystems from exogenous chemicals
requires information on both hazard and exposure. The US Environmental Protection …