Background: Angiogenesis, the formation of new blood vessels, is an integral part of both
normal developmental processes and numerous pathologies, ranging from tumor growth …

Metastatic spread of cancer cells is the main cause of death of breast cancer patients, and
elucidation of the molecular mechanisms underlying this process is a major focus in cancer …

Obesity is an increasingly prevalent human condition in developed societies. Despite major
progress in the understanding of the molecular mechanisms leading to obesity, no safe and …

The molecular diversity of receptors in human blood vessels remains largely unexplored.
We developed a selection method in which peptides that home to specific vascular beds are …

The ultimate goal of proteomics is to characterize the information flow through protein
networks. This information can be a cause, or a consequence, of disease processes. Clinical …

Antitumor monoclonal antibodies have shown clinical promise as cancer cell surface
targeting agents. More tumor targeting antibodies are likely to be approved by the FDA in the …

The inherently toxic nature of chemotherapy drugs is essential for them to kill cancer cells
but is also the source of the detrimental side effects experienced by patients. One strategy to …

Recognition of molecular diversity of cell surface proteomes in disease is essential for the
development of targeted therapies. Progress in targeted therapeutics requires establishing …

The poor selective toxicity of chemotherapeutic anticancer drugs leads to dose-limiting side
effects that compromise clinical outcome. Solid tumors recruit new blood vessels to support …

Recognition of molecular diversity in disease is required for the development of targeted
therapies. We have developed a screening method based on phage display to select …