Transient receptor potential (TRP) channels are a widely expressed family of 28
evolutionarily conserved cationic ion channels that operate as primary detectors of chemical …

When light is absorbed within the outer segment of a vertebrate photoreceptor, the
conformation of the photopigment rhodopsin is altered to produce an activated photoproduct …

The basis of the duplex theory of vision is examined in view of the dazzling array of data on
visual pigment sequences and the pigments they form, on the microspectrophotometry …

Publisher Summary This chapter discusses the research that has characterized the G-
protein cascade of transduction in vertebrate photoreceptors, with particular emphasis on …

For decades, photoreceptors have been an outstanding model system for elucidating basic
principles in sensory transduction and biochemistry and for understanding many facets of …

One hundred and fifty years ago Max Schultze first proposed the duplex theory of vision, that
vertebrate eyes have two types of photoreceptor cells with differing sensitivity: rods for dim …

We have used recent measurements of mammalian cone light responses and voltage-gated
currents to calculate cone ATP utilization and compare it to that of rods. The largest …

In the vertebrate retina, rods and cones both detect light, but they differ in functional aspects
such as light sensitivity and temporal resolution, and in some cell biological aspects. For …

How are sights and sounds and smells converted into electrical signals in a form that can be
interpreted by the nervous system? Although this process, called sensory transduction …

A 10 μm spot of argon laser light was focused onto the outer segments of intact mouse rods
loaded with fluo‐3, fluo‐4 or fluo‐5F, to estimate dark, resting free Ca2+ concentration …