The signal recognition particle (SRP) and its receptor compose a universally conserved and
essential cellular machinery that couples the synthesis of nascent proteins to their proper …

Most secreted and many membrane proteins contain cleavable N-terminal signal sequences
that mediate their targeting to and translocation across the endoplasmic reticulum or …

INTRODUCTION Cells synthesize glucose if deprived of it, and destroy gluconeogenic
enzymes upon return to glucose-replete conditions. Gluconeogenesis (de novo synthesis of …

The evolutionary emergence of organelles was a defining process in diversifying
biochemical reactions within the cell and enabling multicellularity. However …

Protein secretion is an essential process for living organisms. In eukaryotes, this
encompasses numerous steps mediated by several hundred cellular proteins. The core …

The trimeric Sec61/SecY complex is a protein-conducting channel (PCC) for secretory and
membrane proteins. Although Sec complexes can form oligomers, it has been suggested …

We carried out a large-scale screen to identify interactions between integral membrane
proteins of Saccharomyces cerevisiae by using a modified split-ubiquitin technique. Among …

Biological processes are regulated to provide cells with exquisite adaptability to changing
environmental conditions and cellular demands. The mechanisms regulating secretory and …

We have identified all homologues in the current databases of the ubiquitous protein
constituents of the general secretory (Sec) pathway. These prokaryotic/eukaryotic proteins …

Numerous proteins targeted for the secretory pathway are increasingly implicated in
functional or pathological roles at alternative cellular destinations. The parameters that allow …