Evaluation of brucellosis vaccines: a comprehensive review

M Heidary, S Dashtbin, R Ghanavati… - Frontiers in Veterinary …, 2022 - frontiersin.org
Brucellosis is a bacterial zoonosis caused by Brucella spp. which can lead to heavy
economic losses and severe human diseases. Thus, controlling brucellosis is very …

[HTML][HTML] A designed peptide-based vaccine to combat Brucella melitensis, B. suis and B. abortus: Harnessing an epitope mapping and immunoinformatics approach

H Tarrahimofrad, J Zamani, MR Hamblin… - Biomedicine & …, 2022 - Elsevier
Vaccines against Brucella abortus, B. melitensis and B. suis have been based on weakened
or killed bacteria, however there is no recombinant vaccine for disease prevention or …

Design of a new multi-epitope vaccine against Brucella based on T and B cell epitopes using bioinformatics methods

Z Chen, Y Zhu, T Sha, Z Li, Y Li, F Zhang… - Epidemiology & …, 2021 - cambridge.org
Brucellosis is one of the most serious and widespread zoonotic diseases, which seriously
threatens human health and the national economy. This study was based on the T/B …

Novel multi-epitope vaccine against bovine brucellosis: approach from immunoinformatics to expression

S Rahimnahal, S Yousefizadeh… - Journal of Biomolecular …, 2023 - Taylor & Francis
Brucellosis is a zoonotic caused by the Brucella which is a well-known infectious disease
agent in domestic animals and if transmitted, it can cause infection in humans. Because …

Immunization with a combination of recombinant Brucella abortus proteins induces T helper immune response and confers protection against wild‐type challenge in …

Z Li, S Wang, S Wei, G Yang, C Zhang… - Microbial …, 2022 - Wiley Online Library
Protective efficiency of a combination of four recombinant Brucella abortus (B. abortus)
proteins, namely, ribosomal protein L7/L12, outer membrane protein (OMP) 22, OMP25 and …

Pulmonary mucosal immunity mediated through CpG provides adequate protection against pulmonary Mycobacterium tuberculosis infection in the mouse model. A …

A Troy, SC Esparza-Gonzalez, A Bartek, E Creissen… - Tuberculosis, 2020 - Elsevier
Abstract Toll-Like Receptor (TLR) 9 stimulation is required for induction of potent immune
responses against pathogen invasion. The use of unmethylated CpG as adjuvants in …

Evaluation of immunogenicity of novel multi-epitope subunit vaccines in combination with poly I: C against Brucella melitensis and Brucella abortus infection

Z Sadeghi, M Fasihi-Ramandi, S Bouzari - International …, 2019 - Elsevier
Brucellosis is a worldwide zoonotic disease affecting domestic animals and humans. Due to
several safety problems associated with live attenuated vaccines (Rev1 and RB51), it is …

Brucella antigens (BhuA, 7α-HSDH, FliC) in poly I: C adjuvant as potential vaccine candidates against brucellosis

Z Sadeghi, M Fasihi-Ramandi, S Bouzari - Journal of Immunological …, 2022 - Elsevier
A promising strategy for controlling animal brucellosis is vaccination with commercial
vaccine strains (Brucella melitensis Rev. 1 and Brucella abortus RB51). Owing to safety …

Состояние проблемы разработки новых вакцин против бруцеллеза

ВИ Дятлова - Бактериология, 2019 - elibrary.ru
Бруцеллез остается актуальной проблемой для отечественной ветеринарии и
медицины. Это заболевание наносит не только экономический ущерб, обусловленный …