Nitrogen containing heterocycles as anticancer agents: a medicinal chemistry perspective

A Kumar, AK Singh, H Singh, V Vijayan, D Kumar… - Pharmaceuticals, 2023 - mdpi.com
Cancer is one of the major healthcare challenges across the globe. Several anticancer
drugs are available on the market but they either lack specificity or have poor safety, severe …

Structure-activity relationship (SAR) study and design strategies of nitrogen-containing heterocyclic moieties for their anticancer activities

J Akhtar, AA Khan, Z Ali, R Haider, MS Yar - European journal of medicinal …, 2017 - Elsevier
The present review article offers a detailed account of the design strategies employed for the
synthesis of nitrogen-containing anticancer agents. The results of different studies describe …

Concept of hybrid drugs and recent advancements in anticancer hybrids

AK Singh, A Kumar, H Singh, P Sonawane, H Paliwal… - Pharmaceuticals, 2022 - mdpi.com
Cancer is a complex disease, and its treatment is a big challenge, with variable efficacy of
conventional anticancer drugs. A two-drug cocktail hybrid approach is a potential strategy in …

Therapeutic evolution of benzimidazole derivatives in the last quinquennial period

W Akhtar, MF Khan, G Verma… - European journal of …, 2017 - Elsevier
Benzimidazole, a fused heterocycle bearing benzene and imidazole has gained
considerable attention in the field of contemporary medicinal chemistry. The moiety is of …

Pyrimidine: a review on anticancer activity with key emphasis on SAR

A Mahapatra, T Prasad, T Sharma - Future journal of pharmaceutical …, 2021 - Springer
Background Cancer is a global health challenge, it impacts the quality of life and its
treatment is associated with several side effects. Resistance of the cancer cells to the …

Anti-cancer nitrogen-containing heterocyclic compounds

Z Hosseinzadeh, A Ramazani… - Current Organic …, 2018 - benthamdirect.com
Cancer is one of the leading causes of death worldwide. Mutation of the cell regulates genes
and protein causing cancer. Surgery, radiotherapy, and the use of anticancer agents are the …

Design, synthesis, docking and QSAR study of substituted benzimidazole linked oxadiazole as cytotoxic agents, EGFR and erbB2 receptor inhibitors

MJ Akhtar, AA Siddiqui, AA Khan, Z Ali… - European Journal of …, 2017 - Elsevier
The synthesis of benzimidazole linked oxadiazole derivatives designed as potential EGFR
and erbB2 receptor inhibitors with anticancer and apoptotic activity were studied …

Synthesis of stable benzimidazole derivatives bearing pyrazole as anticancer and EGFR receptor inhibitors

MJ Akhtar, AA Khan, Z Ali, RP Dewangan, M Rafi… - Bioorganic …, 2018 - Elsevier
A new series of benzimidazole linked pyrazole derivatives were synthesized by
cyclocondensation reaction through one-pot multicomponent reaction in absolute ethanol …

Recent progress of benzimidazole hybrids for anticancer potential

MJ Akhtar, MS Yar, VK Sharma, AA Khan… - Current Medicinal …, 2020 - benthamdirect.com
This review presents the detailed account of factors leading to cancer and design strategy
for the synthesis of benzimidazole derivatives as anticancer agents. The recent survey for …

Perspectives of benzimidazole derivatives as anticancer agents in the new era

S Yadav, B Narasimhan - Anti-Cancer Agents in Medicinal …, 2016 - ingentaconnect.com
Cancer is one of the deadliest diseases nowadays and is a great topic for research as the
challenging task is to develop new entities with selectivity towards cancerous cells …