Cleavage of nascent transcripts is a fundamental process for eukaryotic mRNA maturation
and for the production of different mRNA isoforms. In eukaryotes, cleavage of mRNA …

Receiving a neurodegenerative disease (NDD) diagnosis, such as Alzheimer's disease,
Parkinson's disease, Huntington's disease, or amyotrophic lateral sclerosis, is devastating …

Isopenicillin N synthase (IPNS) catalyzes the unique reaction of l-δ-(α-aminoadipoyl)-l-
cysteinyl-d-valine (ACV) with dioxygen giving isopenicillin N (IPN), the precursor of all …

Antibiotic resistance (AR) remains one of the leading global health challenges, mostly
implicated in disease-related deaths. The Enterobacteriaceae-producing metallo-β …

JTE-607 is a small molecule that was developed as an inflammatory cytokine inhibitor and
also as an anti-leukemia reagent for monocytic leukemia. However, the mode of action of …

Cleavage by the endonuclease CPSF73 and polyadenylation of nascent RNA is an
essential step in co-transcriptional mRNA maturation. Recent work has surprisingly …

D-psicose 3-epimerase (DPEase) catalyzes the isomerization of D-fructose to D-psicose
(aka D-allulose, a low-calorie sweetener), but its industrial application has been restricted by …

Protein sequence similarity networks (SSNs) constitute a convenient approach to analyze
large polypeptide sequence datasets, and have been successfully applied to study a …

Cuprous copper (Cu (I)) is an essential cofactor for enzymes supporting many cellular
functions including mitochondrial respiration and suppression of oxidative stress. Neurons …

Alzheimer disease (AD) is characterized by deterioration of cognitive capabilities with an
estimated 44 million individuals worldwide living with it. Beyond memory deficits, the most …