New observations in neuroscience using superresolution microscopy

M Igarashi, M Nozumi, LG Wu, FC Zanacchi… - Journal of …, 2018 - Soc Neuroscience
Superresolution microscopy (SM) techniques are among the revolutionary methods for
molecular and cellular observations in the 21st century. SM techniques overcome optical …

[HTML][HTML] Regulation of actin filament assembly and disassembly in growth cone motility and axon guidance

F Schneider, I Metz, MB Rust - Brain Research Bulletin, 2023 - Elsevier
Directed outgrowth of axons is fundamental for the establishment of neuronal networks.
Axon outgrowth is guided by growth cones, highly motile structures enriched in filamentous …

[HTML][HTML] Growth cone phosphoproteomics reveals that GAP-43 phosphorylated by JNK is a marker of axon growth and regeneration

A Kawasaki, M Okada, A Tamada, S Okuda, M Nozumi… - Iscience, 2018 - cell.com
Neuronal growth cones are essential for nerve growth and regeneration, as well as for the
formation and rearrangement of the neural network. To elucidate phosphorylation …

The functional architecture of axonal actin

MJ Papandréou, C Leterrier - Molecular and Cellular Neuroscience, 2018 - Elsevier
The cytoskeleton builds and supports the complex architecture of neurons. It orchestrates
the specification, growth, and compartmentation of the axon: axon initial segment, axonal …

[HTML][HTML] Neuronal signaling involved in neuronal polarization and growth: lipid rafts and phosphorylation

M Igarashi, A Honda, A Kawasaki… - Frontiers in Molecular …, 2020 - frontiersin.org
Neuronal polarization and growth are developmental processes that occur during neuronal
cell differentiation. The molecular signaling mechanisms involved in these events in in vivo …

Molecular basis of the functions of the mammalian neuronal growth cone revealed using new methods

M Igarashi - Proceedings of the Japan Academy, Series B, 2019 - jstage.jst.go.jp
The neuronal growth cone is a highly motile, specialized structure for extending neuronal
processes. This structure is essential for nerve growth, axon pathfinding, and accurate …

Identification of z‐axis filopodia in growth cones using super‐resolution microscopy

M Nozumi, Y Sato, M Nishiyama‐Usuda… - Journal of …, 2024 - Wiley Online Library
A growth cone is a highly motile tip of an extending axon that is crucial for neural network
formation. Three‐dimensional‐structured illumination microscopy, a type of super‐resolution …

Phosphoproteomic and bioinformatic methods for analyzing signaling in vertebrate axon growth and regeneration

M Igarashi, A Kawasaki, Y Ishikawa, A Honda… - Journal of Neuroscience …, 2020 - Elsevier
Phosphorylation is the most important post-translational modification of proteins in many
cells, including neurons. Phosphoproteomics is a relatively new technique for …

TOM-1/tomosyn acts with the UNC-6/netrin receptor UNC-5 to inhibit growth cone protrusion in Caenorhabditis elegans

SS Mahadik, EA Lundquist - Development, 2023 - journals.biologists.com
In the polarity/protrusion model of growth cone repulsion from UNC-6/netrin, UNC-6 first
polarizes the growth cone of the VD motor neuron axon via the UNC-5 receptor, and then …

Regulation of Cellular Adhesion and Cytoskeletal Remodeling in Neurodevelopment: Functional Roles for Beta-Chimaerins and the Crk-Associated Substrate (Cas) …

JA Estep - 2022 - search.proquest.com
Proper nervous system function requires neurons to make synaptic connections with the
appropriate partners, ensuring the formation of precise circuits. Even transient …