Nowadays, nitrogenous heterocyclic molecules have attracted a great deal of interest
among medicinal chemists. Among these potential heterocyclic drugs, benzimidazole …

In antimalarial drug development research, overcoming drug resistance has been a major
challenge for researchers. Nowadays, several drugs like chloroquine, mefloquine …

The continued emergence of resistance to front-line antimalarial treatments is of great
concern. Therefore, new compounds that potentially have a novel target in various …

Malaria remains a major public health problem. With the loss of antimalarials to resistance,
the malaria burden will likely continue for decades. New antimalarial scaffolds are crucial to …

Benzimidazoles, such as albendazole, thiabendazole and omeprazole have antiplasmodial
activity against Plasmodium falciparum and are widely used as scaffolds for metal-based …

A transition metal-free and efficient synthesis of fused azapolycycles via a multicomponent
reaction has been developed using mucohalic acid as a C3 synthon. The reaction promoted …

A novel series of antimalarial benzimidazole derivatives incorporating phenolic Mannich
base side chains at the C2 position, which possess dual asexual blood and sexual stage …

Malaria cases and deaths keep being excessively high every year. Some inroads gained in
the last two decades have been eroded especially due to the surge of resistance to most …

Helminth infections are one of the most prevalent parasitic diseases affecting animals and
humans worldwide. Anthelmintic resistance to the main drugs used to control these …

A novel 2, 8-disubstituted-1, 5-naphthyridine hit compound stemming from the open access
Medicines for Malaria Venture Pathogen Box formed a basis for a hit-to-lead medicinal …