Due to the biological importance of nucleotides and related species, such as XNP (where X=
adenosine (A), uridine (U), cytidine (C), guanosine (G), and N= mono, di, tri), FAD and …

In recent years, a substantial body of evidence has emerged demonstrating that purine and
pyrimidine synthesis and metabolism play major roles in controlling embryonic and fetal …

Long considered merely a trophic and mechanical support to neurons, astrocytes have
progressively taken the center stage as their ability to react to acute and chronic …

Modeling human neuronal properties in physiological and pathological conditions is
essential to identify novel potential drugs and to explore pathological mechanisms of …

NG2‐expressing cells comprise a population of cycling precursors that can exit the cell cycle
and differentiate into mature oligodendrocytes. As a whole, they display heterogeneous …

During a systemic inflammatory response endothelial-expressed surface molecules have
been strongly implicated in orchestrating immune responses. Previous studies have shown …

New brain synapses form when a postsynaptic structure, the dendritic spine, interacts with a
presynaptic terminal. Brain synapses and dendritic spines, membrane-rich structures, are …

In the adult nervous system, the major source of nucleotide synthesis is the salvage
pathway. Uridine is the major form of pyrimidine nucleosides taken up by the brain. Uridine …

Upon central nervous system injury, the extracellular concentrations of nucleotides and
cysteinyl-leukotrienes, two unrelated families of endogenous signalling molecules, are …

Remyelination, namely, the formation of new myelin sheaths around denuded axons,
counteracts axonal degeneration and restores neuronal function. Considerable advances …