Store-operated calcium channels (SOCs) are a major pathway for calcium signaling in
virtually all metozoan cells and serve a wide variety of functions ranging from gene …

Cytosolic Ca 2+ concentration levels fluctuate in an ordered manner along the cell cycle, in
line with the fact that Ca 2+ is involved in the regulation of cell proliferation. Cell proliferation …

Cell proliferation is orchestrated through diverse proteins related to calcium (Ca 2+)
signaling inside the cell. Cellular Ca 2+ influx that occurs first by various mechanisms at the …

Introduction• I CRAC• Orais• STIM1• STIM2• STIM1, STIM2 and Ca2+ oscillations• TRPCs
and SOCE• Conclusions The process of store‐operated Ca2+ entry (SOCE), whereby Ca2+ …

The endoplasmic reticulum (ER) is a morphologically and functionally diverse organelle
capable of integrating multiple extracellular and internal signals and generating adaptive …

Eukaryotic organelles can interact with each other through stable junctions where the two
membranes are kept in close apposition. The junction that connects the endoplasmic …

Stromal interaction molecule 1 (STIM1) stimulates calcium ion (Ca2+) entry through plasma
membrane Orai1 channels in response to decreased Ca2+ concentrations in the …

The molecular nature of calcium (Ca 2+)-dependent mechanisms and the ion channels
having a major role in the apoptosis of cancer cells remain a subject of debate. Here, we …

Store-operated calcium channels (SOCs) are a nearly ubiquitous Ca2+ entry pathway
stimulated by numerous cell surface receptors via the reduction of Ca2+ concentration in the …

Key points Pharmacological and molecular inhibition of transient receptor potential
melastatin 7 (TRPM7) reduces store‐operated calcium entry (SOCE). Overexpression of …