Optogenetics for light control of biological systems
Optogenetic techniques have been developed to allow control over the activity of selected
cells within a highly heterogeneous tissue, using a combination of genetic engineering and …
cells within a highly heterogeneous tissue, using a combination of genetic engineering and …
Neurodevelopment of the association cortices: Patterns, mechanisms, and implications for psychopathology
The human brain undergoes a prolonged period of cortical development that spans multiple
decades. During childhood and adolescence, cortical development progresses from lower …
decades. During childhood and adolescence, cortical development progresses from lower …
Glioblastoma remodelling of human neural circuits decreases survival
Gliomas synaptically integrate into neural circuits,. Previous research has demonstrated
bidirectional interactions between neurons and glioma cells, with neuronal activity driving …
bidirectional interactions between neurons and glioma cells, with neuronal activity driving …
Next-generation GRAB sensors for monitoring dopaminergic activity in vivo
Dopamine (DA) plays a critical role in the brain, and the ability to directly measure
dopaminergic activity is essential for understanding its physiological functions. We therefore …
dopaminergic activity is essential for understanding its physiological functions. We therefore …
Electrical and synaptic integration of glioma into neural circuits
HS Venkatesh, W Morishita, AC Geraghty, D Silverbush… - Nature, 2019 - nature.com
High-grade gliomas are lethal brain cancers whose progression is robustly regulated by
neuronal activity. Activity-regulated release of growth factors promotes glioma growth, but …
neuronal activity. Activity-regulated release of growth factors promotes glioma growth, but …
A preoptic neuronal population controls fever and appetite during sickness
During infection, animals exhibit adaptive changes in physiology and behaviour aimed at
increasing survival. Although many causes of infection exist, they trigger similar stereotyped …
increasing survival. Although many causes of infection exist, they trigger similar stereotyped …
Rapid eye movement sleep is initiated by basolateral amygdala dopamine signaling in mice
E Hasegawa, A Miyasaka, K Sakurai, Y Cherasse, Y Li… - Science, 2022 - science.org
The sleep cycle is characterized by alternating non–rapid eye movement (NREM) and rapid
eye movement (REM) sleeps. The mechanisms by which this cycle is generated are …
eye movement (REM) sleeps. The mechanisms by which this cycle is generated are …
[HTML][HTML] Targeted activation of hippocampal place cells drives memory-guided spatial behavior
The hippocampus is crucial for spatial navigation and episodic memory formation.
Hippocampal place cells exhibit spatially selective activity within an environment and have …
Hippocampal place cells exhibit spatially selective activity within an environment and have …
Excitation-inhibition balance as a framework for investigating mechanisms in neuropsychiatric disorders
VS Sohal, JLR Rubenstein - Molecular psychiatry, 2019 - nature.com
Abstract In 2003 Rubenstein and Merzenich hypothesized that some forms of Autism (ASD)
might be caused by a reduction in signal-to-noise in key neural circuits, which could be the …
might be caused by a reduction in signal-to-noise in key neural circuits, which could be the …
The emergence and influence of internal states
Animal behavior is shaped by a variety of" internal states"—partially hidden variables that
profoundly shape perception, cognition, and action. The neural basis of internal states, such …
profoundly shape perception, cognition, and action. The neural basis of internal states, such …