Chemical constituents, pharmacological action, antitumor application, and toxicity of strychnine semen from Strychnons pierriana AW Hill.: a review
W Liu, X Tang, C Fan, G He, X Wang, X Liang… - Journal of …, 2023 - Elsevier
Ethnopharmacological relevance The dried and mature seeds of Strychnons pierriana AW
Hill. have been called Strychnine Semen (S. Semen). It have been used in traditional …
Hill. have been called Strychnine Semen (S. Semen). It have been used in traditional …
Brucine-induced neurotoxicity by targeting caspase 3: Involvement of PPARγ/NF-κB/apoptosis signaling pathway
Y Lei, F Hou, X Wu, Y Yi, F Xu, Q Gong, J Gao - Neurotoxicity Research, 2022 - Springer
Brucine, a weak alkaline indole alkaloid, is one of the main bioactive and toxic constituents
of Strychnos nux-vomica L., which exerts multiple pharmacological activities, such as anti …
of Strychnos nux-vomica L., which exerts multiple pharmacological activities, such as anti …
Pharmacological Effects, Pharmacokinetics, and Strategies to Reduce Brucine Toxicity
L Zhang, W Yu - Revista Brasileira de Farmacognosia, 2021 - Springer
Semen strychni, the seed of Strychnos nux-vomica L., Loganiaceae, has been widely used
in China for a long history. Brucine, one of the main bioactive alkaloids from these seeds …
in China for a long history. Brucine, one of the main bioactive alkaloids from these seeds …
Chronotoxicity of Semen Strychni is associated with circadian metabolism and transport in mice
Objectives We aimed to determine the circadian responses of mice to Semen Strychni and to
investigate the role of pharmacokinetics in generating chronotoxicity. Methods Total extract …
investigate the role of pharmacokinetics in generating chronotoxicity. Methods Total extract …
Isoliquiritigenin alleviates semen strychni-induced neurotoxicity by restoring the metabolic pathway of neurotransmitters in rats
L Wang, M Zhang, J Wen, Y Xiang, X Duan… - Frontiers in …, 2021 - frontiersin.org
Acute neurotoxicity of Semen Strychni can result in sudden death in epilepsy. The
detoxification method and mechanism of Semen Strychni acute poisoning have not been …
detoxification method and mechanism of Semen Strychni acute poisoning have not been …
Sample preparation techniques for protein binding measurement in radiopharmaceutical approaches: A short review
MM Moein, C Halldin - Talanta, 2020 - Elsevier
Plasma protein binding (PPB) measurement is a key step in radiopharmaceutical studies for
the development of positron emission tomography (PET) radioligands. PPB refers to the …
the development of positron emission tomography (PET) radioligands. PPB refers to the …
Development of a UPLC–MS/MS method for the determination of active ingredients of Shuang Hu in rat blood and its application in pharmacokinetics
XR Jiang, MY Lei, LX Qin, YL Zhou… - Biomedical …, 2023 - Wiley Online Library
A simple and sensitive method using in vivo microdialysis coupled with UPLC–MS/MS was
established to evaluate the pharmacokinetics of Shuang Hu tincture (SHZTN). Xevo TQ‐S …
established to evaluate the pharmacokinetics of Shuang Hu tincture (SHZTN). Xevo TQ‐S …