The myelination of axons has evolved to enable fast and efficient transduction of electrical
signals in the vertebrate nervous system. Acting as an electric insulator, the myelin sheath is …

Mature myelinating oligodendrocytes, the cells that produce the myelin sheath that insulates
axons in the central nervous system, have distinct energetic and metabolic requirements …

Information storage and transfer in the brain require a high computational power. Neuronal
network display various local or global mechanisms to allow information storage and …

Multiple sclerosis (MS) is an autoimmune disease, governed by oligodendrocyte (OL)
dystrophy and central nervous system (CNS) demyelination manifesting variable …

Synaptic communication is an important process in the central nervous system that allows
for the rapid and spatially specified transfer of signals. Neurons receive various synaptic …

In people with multiple sclerosis (MS), newborn and surviving oligodendrocytes (OLs) can
contribute to remyelination, however, current therapies are unable to enhance or sustain …

Alzheimer's disease poses a significant global health challenge owing to the progressive
cognitive decline of patients and absence of curative treatments. The current therapeutic …

Dysfunctional glial cells play a pre-eminent role in schizophrenia pathophysiology. Post-
mortem studies have provided evidence for significantly decreased glial cell numbers in …

Introduction Glucose Transporter 1-Deficiency Syndrome (GLUT1-DS) is a rare genetic
disorder caused by mutations in the gene encoding for GLUT1 and characterized by …

Axon regeneration requires the mobilization of intracellular resources, including proteins,
lipids, and nucleotides. After injury, neurons need to adapt their metabolism to meet the …