Salivary hypofunction: an update on aetiology, diagnosis and therapeutics

J Saleh, MAZ Figueiredo, K Cherubini, FG Salum - Archives of oral biology, 2015 - Elsevier
Saliva is of paramount importance for the maintenance of oral and general homeostasis.
Salivary hypofunction predispose patients to disorders such as dysgeusia, pain and burning …

[HTML][HTML] Autologous mesenchymal stem cells offer a new paradigm for salivary gland regeneration

M Marinkovic, ON Tran, H Wang… - International Journal of …, 2023 - nature.com
Salivary gland (SG) dysfunction, due to radiotherapy, disease, or aging, is a clinical
manifestation that has the potential to cause severe oral and/or systemic diseases and …

Concise review: salivary gland regeneration: therapeutic approaches from stem cells to tissue organoids

I Lombaert, MM Movahednia, C Adine, JN Ferreira - Stem cells, 2017 - academic.oup.com
The human salivary gland (SG) has an elegant architecture of epithelial acini, connecting
ductal branching structures, vascular and neuronal networks that together function to …

Injectable decellularized extracellular matrix hydrogel promotes salivary gland regeneration via endogenous stem cell recruitment and suppression of fibrogenesis

T Wang, Q Huang, Z Rao, F Liu, X Su, X Zhai, J Ma… - Acta Biomaterialia, 2023 - Elsevier
Saliva is key to the maintenance of oral homeostasis. However, several forms of salivary
gland (SG) disorders, followed by hyposalivation, often result in dental caries, oral infection …

Salivary gland development: a template for regeneration

VN Patel, MP Hoffman - Seminars in cell & developmental biology, 2014 - Elsevier
The mammalian salivary gland develops as a highly branched structure designed to
produce and secrete saliva. This review will focus on research on mouse submandibular …

[HTML][HTML] Mouth-watering results: Clinical need, current approaches, and future directions for salivary gland regeneration

C Rocchi, E Emmerson - Trends in molecular medicine, 2020 - cell.com
Permanent damage to the salivary glands and resulting hyposalivation and xerostomia have
a substantial impact on patient health, quality of life, and healthcare costs. Currently, patients …

[HTML][HTML] Bioengineering in salivary gland regeneration

M Hajiabbas, C D'Agostino, J Simińska-Stanny… - Journal of biomedical …, 2022 - Springer
Salivary gland (SG) dysfunction impairs the life quality of many patients, such as patients
with radiation therapy for head and neck cancer and patients with Sjögren's syndrome …

[HTML][HTML] Resveratrol inhibits ionising irradiation-induced inflammation in MSCs by activating SIRT1 and limiting NLRP-3 inflammasome activation

Y Fu, Y Wang, L Du, C Xu, J Cao, T Fan, J Liu… - International journal of …, 2013 - mdpi.com
IL-1β, a pro-inflammatory cytokine, has been shown to contribute to radiation injury. Sirt1, an
NAD+-dependent class III protein deacetylase, plays an important role in the regulation of …

[HTML][HTML] Systemic transplantation of human adipose tissue-derived mesenchymal stem cells for the regeneration of irradiation-induced salivary gland damage

JY Lim, JC Ra, IS Shin, YH Jang, HY An, JS Choi… - PloS one, 2013 - journals.plos.org
Objectives Cell-based therapy has been reported to repair or restore damaged salivary
gland (SG) tissue after irradiation. This study was aimed at determining whether systemic …

[HTML][HTML] Neurotrophic factor GDNF promotes survival of salivary stem cells

N Xiao, Y Lin, H Cao, D Sirjani… - The Journal of …, 2014 - Am Soc Clin Investig
Stem cell–based regenerative therapy is a promising treatment for head and neck cancer
patients that suffer from chronic dry mouth (xerostomia) due to salivary gland injury from …