Neurobiology of BDNF in fear memory, sensitivity to stress, and stress-related disorders
M Notaras, M van den Buuse - Molecular psychiatry, 2020 - nature.com
Brain-derived neurotrophic factor (BDNF) is widely accepted for its involvement in resilience
and antidepressant drug action, is a common genetic locus of risk for mental illnesses, and …
and antidepressant drug action, is a common genetic locus of risk for mental illnesses, and …
Structure, function, and regulation of the Hsp90 machinery
MM Biebl, J Buchner - Cold Spring Harbor perspectives …, 2019 - cshperspectives.cshlp.org
Heat shock protein 90 (Hsp90) is a molecular chaperone involved in the maturation of a
plethora of substrates (“clients”), including protein kinases, transcription factors, and E3 …
plethora of substrates (“clients”), including protein kinases, transcription factors, and E3 …
SKP2 attenuates autophagy through Beclin1-ubiquitination and its inhibition reduces MERS-Coronavirus infection
Autophagy is an essential cellular process affecting virus infections and other diseases and
Beclin1 (BECN1) is one of its key regulators. Here, we identified S-phase kinase-associated …
Beclin1 (BECN1) is one of its key regulators. Here, we identified S-phase kinase-associated …
Holocaust exposure induced intergenerational effects on FKBP5 methylation
R Yehuda, NP Daskalakis, LM Bierer, HN Bader… - Biological …, 2016 - Elsevier
Background The involvement of epigenetic mechanisms in intergenerational transmission of
stress effects has been demonstrated in animals but not in humans. Methods Cytosine …
stress effects has been demonstrated in animals but not in humans. Methods Cytosine …
Pitfalls of the MTT assay: Direct and off-target effects of inhibitors can result in over/underestimation of cell viability
AA Stepanenko, VV Dmitrenko - Gene, 2015 - Elsevier
The MTT assay (to a less degree MTS, XTT or WST) is a widely exploited approach for
measuring cell viability/drug cytotoxicity. MTT reduction occurs throughout a cell and can be …
measuring cell viability/drug cytotoxicity. MTT reduction occurs throughout a cell and can be …
Progesterone as an anti-inflammatory drug and immunomodulator: new aspects in hormonal regulation of the inflammation
TA Fedotcheva, NI Fedotcheva, NL Shimanovsky - Biomolecules, 2022 - mdpi.com
The specific regulation of inflammatory processes by steroid hormones has been actively
studied in recent years, especially by progesterone (P4) and progestins. The mechanisms of …
studied in recent years, especially by progesterone (P4) and progestins. The mechanisms of …
The role of decidual cells in uterine hemostasis, menstruation, inflammation, adverse pregnancy outcomes and abnormal uterine bleeding
F Schatz, O Guzeloglu-Kayisli, S Arlier… - Human reproduction …, 2016 - academic.oup.com
BACKGROUND Human pregnancy requires robust hemostasis to prevent hemorrhage
during extravillous trophoblast (EVT) invasion of the decidualized endometrium, modification …
during extravillous trophoblast (EVT) invasion of the decidualized endometrium, modification …
Selective inhibitors of the FK506-binding protein 51 by induced fit
S Gaali, A Kirschner, S Cuboni, J Hartmann… - Nature chemical …, 2015 - nature.com
Abstract The FK506-binding protein 51 (FKBP51, encoded by the FKBP5 gene) is an
established risk factor for stress-related psychiatric disorders such as major depression …
established risk factor for stress-related psychiatric disorders such as major depression …
FKBP ligands—where we are and where to go?
JM Kolos, AM Voll, M Bauder, F Hausch - Frontiers in pharmacology, 2018 - frontiersin.org
In recent years, many members of the FK506-binding protein (FKBP) family were
increasingly linked to various diseases. The binding domain of FKBPs differs only in a few …
increasingly linked to various diseases. The binding domain of FKBPs differs only in a few …
Regulatory and mechanistic actions of glucocorticoids on T and inflammatory cells
AC Liberman, ML Budziñski, C Sokn… - Frontiers in …, 2018 - frontiersin.org
Glucocorticoids (GCs) play an important role in regulating the inflammatory and immune
response and have been used since decades to treat various inflammatory and autoimmune …
response and have been used since decades to treat various inflammatory and autoimmune …