This review examines the state of Bayesian thinking as Statistics in Medicine was launched
in 1982, reflecting particularly on its applicability and uses in medical research. It then looks …

This paper surveys in detail the relations between numerical integration and the Hamiltonian
(or hybrid) Monte Carlo method (HMC). Since the computational cost of HMC mainly lies in …

The master regulator for entry into sporulation in Bacillus subtilis is the DNA‐binding protein
Spo0A, which has been found to influence, directly or indirectly, the expression of over 500 …

Asymmetric division during sporulation by Bacillus subtilis generates a mother cell that
undergoes a 5-h program of differentiation. The program is governed by a hierarchical …

The DNA motif discovery (MD) problem is the main challenge of genome biology, and its
importance is directly proportional to increasing sequencing technologies. MD plays a vital …

The DNA motif discovery is a primary step in many systems for studying gene function. Motif
discovery plays a vital role in identification of Transcription Factor Binding Sites (TFBSs) that …

We introduce a new sampling algorithm, the equi-energy sampler, for efficient statistical
sampling and estimation. Complementary to the widely used temperature-domain methods …

Background There has been a growing interest in computational discovery of regulatory
elements, and a multitude of motif discovery methods have been proposed. Computational …

Genome-wide analyses of protein binding sites generate large amounts of data; a ChIP
dataset might contain 10,000 sites. Unbiased motif discovery in such datasets is not …

Motivation: Identification of a transcription factor binding sites is an important aspect of the
analysis of genetic regulation. Many programs have been developed for the de novo …