Biologics and airway remodeling in severe asthma

G Varricchi, S Ferri, J Pepys, R Poto, G Spadaro… - Allergy, 2022 - Wiley Online Library
Asthma is a chronic inflammatory airway disease resulting in airflow obstruction, which in
part can become irreversible to conventional therapies, defining the concept of airway …

Airway remodeling in asthma

KP Hough, ML Curtiss, TJ Blain, RM Liu, J Trevor… - Frontiers in …, 2020 - frontiersin.org
Asthma is an inflammatory disease of the airways that may result from exposure to allergens
or other environmental irritants, resulting in bronchoconstriction, wheezing, and shortness of …

Therapeutic targets in lung tissue remodelling and fibrosis

G Liu, AM Philp, T Corte, MA Travis, H Schilter… - Pharmacology & …, 2021 - Elsevier
Structural changes involving tissue remodelling and fibrosis are major features of many
pulmonary diseases, including asthma, chronic obstructive pulmonary disease (COPD) and …

Predicting postoperative peritoneal metastasis in gastric cancer with serosal invasion using a collagen nomogram

D Chen, Z Liu, W Liu, M Fu, W Jiang, S Xu… - Nature …, 2021 - nature.com
Accurate prediction of peritoneal metastasis for gastric cancer (GC) with serosal invasion is
crucial in clinic. The presence of collagen in the tumour microenvironment affects the …

Airway remodeling heterogeneity in asthma and its relationship to disease outcomes

A Hsieh, N Assadinia, TL Hackett - Frontiers in physiology, 2023 - frontiersin.org
Asthma affects an estimated 262 million people worldwide and caused over 461,000 deaths
in 2019. The disease is characterized by chronic airway inflammation, reversible …

The chemistry and biology of collagen hybridization

X Li, Q Zhang, SM Yu, Y Li - Journal of the American Chemical …, 2023 - ACS Publications
Collagen provides mechanical and biological support for virtually all human tissues in the
extracellular matrix (ECM). Its defining molecular structure, the triple-helix, could be …

IL-37 protects against airway remodeling by reversing bronchial epithelial–mesenchymal transition via IL-24 signaling pathway in chronic asthma

K Feng, P Meng, X Zou, M Zhang, H Li, H Yang… - Respiratory …, 2022 - Springer
Background Epithelial–mesenchymal transition (EMT) is one of the mechanisms of airway
remodeling in chronic asthma. Interleukin (IL)-24 has been implicated in the promotion of …

Airway-on-a-chip: designs and applications for lung repair and disease

TJ Bennet, A Randhawa, J Hua, KC Cheung - Cells, 2021 - mdpi.com
The lungs are affected by illnesses including asthma, chronic obstructive pulmonary
disease, and infections such as influenza and SARS-CoV-2. Physiologically relevant models …

[HTML][HTML] Chronic lung diseases: entangled in extracellular matrix

JK Burgess, MC Harmsen - European Respiratory Review, 2022 - Eur Respiratory Soc
The extracellular matrix (ECM) is the scaffold that provides structure and support to all
organs, including the lung; however, it is also much more than this. The ECM provides …

Epithelial–Mesenchymal Transition Mechanisms in Chronic Airway Diseases: A Common Process to Target?

A Mottais, L Riberi, A Falco, S Soccal, S Gohy… - International journal of …, 2023 - mdpi.com
Epithelial-to-mesenchymal transition (EMT) is a reversible process, in which epithelial cells
lose their epithelial traits and acquire a mesenchymal phenotype. This transformation has …