Astrocytes comprise a heterogeneous cell population characterized by distinct
morphologies, protein expression and function. Unlike neurons, astrocytes do not generate …

Almost fifty years after its first introduction into clinical care, clozapine remains the only
evidence-based pharmacological option for treatment-resistant schizophrenia (TRS), which …

The chemogenetic technology designer receptors exclusively activated by designer drugs
(DREADDs) afford remotely reversible control of cellular signaling, neuronal activity and …

Abstract Muscarinic Designer Receptors Exclusively Activated by Designer Drugs
(DREADD) gated by clozapine-N-oxide (CNO) allow selective G-protein cascade activation …

While calcium imaging has become a mainstay of modern neuroscience, the spectral
properties of current fluorescent calcium indicators limit deep-tissue imaging as well as …

Exaggerated airway constriction triggered by repeated exposure to allergen, also called
hyperreactivity, is a hallmark of asthma. Whereas vagal sensory neurons are known to …

Pain perception is essential for survival and can be amplified or suppressed by
expectations, experiences, and context. The neural mechanisms underlying bidirectional …

Astrocytes play a crucial role in regulating sleep–wake behavior, and adenosine signaling is
generally thought to be involved. Here we show multiple lines of evidence supporting that …

Cognitive and social capacities require postnatal experience, yet the pathways by which
experience guides development are unknown. Here we show that the normal development …

Hyperexcitability in sensory neurons is known to underlie many of the maladaptive changes
associated with persistent pain. Chemogenetics has shown promise as a means to suppress …