Deformability is an essential feature of blood cells (RBCs) that enables them to travel
through even the smallest capillaries of the human body. Deformability is a function of (i) …

Extracellular vesicles (EVs) contribute to several pathophysiological processes and appear
as emerging targets for disease diagnosis and therapy. However, successful translation from …

Red blood cells (RBCs) generate microvesicles to remove damaged cell constituents such
as oxidized hemoglobin and damaged membrane constituents, and thereby prolong their …

Intravascular hemolysis occurs in hereditary, acquired, and iatrogenic hemolytic conditions
but it could be also a normal physiological process contributing to intercellular signaling …

The shedding of extracellular vesicles (EVs) from the red blood cell (RBC) surface is
observed during senescence in vivo and RBC storage in vitro. Two main models for EV …

Extracellular vesicles (EVs) are gaining increasing amounts of attention due to their potential
use in diagnostics and therapy, but the poor reproducibility of the studies that have been …

With the rapid aging in the global population, delay of aging has become a hot research
topic. Lipid rafts (LRs) are microdomains in the plasma membrane that contain sphingolipids …

The oxygen content in the blood may decrease under the influence of various
physicochemical factors and different diseases. The state of hypoxemia is especially …

Hereditary spherocytosis (HS) originates from defective anchoring of the cytoskeletal
network to the transmembrane protein complexes of the red blood cell (RBC). Red cells in …

Red blood cells (RBCs) release hemoglobin (Hb)-containing extracellular vesicles (EVs)
throughout their lifespan in the circulation, and especially during senescence, by spleen …