Protein expression and function in eukaryotic cells are tightly harmonized processes
modulated by the combination of different layers of regulation, including transcription …

Protein oligomers have gained interest, owing to their increased knowledge in cells and
promising utilization for future materials. Various proteins have been shown to 3D domain …

In three-dimensional domain swapping, two protein monomers exchange a part of their
structures to form an intertwined homodimer, whose subunits resemble the monomer …

Human γD (HγD) and γC (HγC) are two-domain crystallin (Crys) proteins expressed in the
nucleus of the eye lens. Structural perturbations in the protein often trigger aggregation …

The initial steps of the folding pathway of the C-terminal domain of the murine prion protein
m PrP (90–231) are predicted based on the sequential collapse model (SCM). A non-local …

This doctoral thesis investigates the molecular principles of protein misfolding, like
threedimensional domain-swapping or amyloid formation. For this purpose, we have used a …