Diabetes mellitus predisposes affected individuals to a significant spectrum of
cardiovascular complications, one of the most debilitating in terms of prognosis is heart …

Over 200 million people suffer from osteoporosis worldwide. Individuals with osteoporosis
have increased rates of bone resorption while simultaneously having impaired …

The hexosamine biosynthesis pathway (HBP) produces uridine diphosphate-N-acetyl
glucosamine, UDP-GlcNAc, which is a key metabolite that is used for N-or O-linked …

In the mid-1980s, the identification of serine and threonine residues on nuclear and
cytoplasmic proteins modified by a N-acetylglucosamine moiety (O-GlcNAc) via an O …

Protein O-linked β-N-acetylglucosamine (O-GlcNAc) modification (O-GlcNAcylation) is a
unique monosaccharide modification discovered in the early 1980s. With the technological …

Reducing infarct size during a cardiac ischaemic‐reperfusion episode is still of paramount
importance, because the extension of myocardial necrosis is an important risk factor for …

In non-small-cell lung cancer (NSCLC), concurrent mutations in the oncogene KRAS and
the tumour suppressor STK11 (also known as LKB1) encoding the kinase LKB1 result in …

The modification of nuclear, mitochondrial, and cytosolic proteins by O-linked βN-
acetylglucosamine (O-GlcNAc) has emerged as a dynamic and essential post-translational …

The development of the foetal heart is driven by increased glucose uptake and activation of
mammalian target of rapamycin (mTOR) and hypoxia‐inducible factor‐1α (HIF‐1α), which …

The cardiovascular system is a complex and well-organized system in which glycosylation
plays a vital role. The heart and vascular wall cells are constituted by an array of specific …