From the realization that cell number homoeostasis is fundamental to the biology of all
metazoans, and that deregulation of this process leads to human diseases, enormous …

Camptothecin (CPT) was discovered from plant extracts more than 60 years ago. Since then,
only two CPT analogues (irinotecan and topotecan) have been approved for cancer …

Paclitaxel (Taxol) is an effective chemotherapeutic agent for treatment of cancer patients.
Despite impressive initial clinical responses, the majority of patients eventually develop …

Background Taxol is one of the most effective chemotherapeutic agents for the treatment of
patients with breast cancer. Despite impressive clinical responses initially, the majority of …

ErbB2 has been shown to activate signaling molecules that may regulate glucose
metabolism. However, there is no evidence reported to directly link ErbB2 to glycolysis, and …

Breast cancer stands as the most prevalent cancer in women globally, and contributes to the
highest percentage of mortality due to cancer-related deaths in women. Paclitaxel (PTX) is …

Paclitaxel is one of the most effective chemotherapy drugs for advanced cervical cancer.
However, acquired resistance of paclitaxel represents a major barrier to successful …

Increasingly, the effectiveness of adjuvant chemotherapy agents for breast cancer has been
related to changes in the genomic profile of tumors. We investigated correspondence …

The median survival of patients with human epidermal growth factor receptor 2 (HER2)-
positive metastatic breast cancer (MBC) has more than doubled, since the discovery of …

In many types of cancer, the expression of the immunoregulatory protein B7-H3 has been
associated with poor prognosis. Previously, we observed a link between B7-H3 and tumor …