Purpose Long-term cancer survivors develop special health issues and specific needs.
Chronic pain, whether the consequence of their cancer or as a side effect of treatment, is …

Background: Demand for cholesterol is high in certain cancers making them potentially
sensitive to therapeutic strategies targeting cellular cholesterol homoeostasis. A potential …

Acute lymphoblastic leukemia is still an incurable disease with resistance to therapy
developing in the majority of patients. We investigated the effect of TPEN, an intracellular …

Background Calcium signaling plays a key role in the regulation of multiple processes in
mammalian mitochondria, from cellular bioenergetics to the induction of stress-induced cell …

Background Numerous reports contend opioids can augment or inhibit malignancy. At
present, there is no consensus on the risk or benefit posed by opioids on malignancy or …

Aim: Recently, D, L-methadone has been put forward as adjuvant treatment in glioblastoma
(GBM). Methods: We analyzed the μ-opioid receptor expression in a set of GBM cell lines …

Apoptotic nuclear morphology and oligonucleosomal double-strand DNA fragments (also
known as DNA ladder) are considered the hallmarks of apoptotic cell death. From a classic …

Although recent decades have seen a significant improvement in the treatment outcome of
leukemia in the pediatric population, those who are treated for relapsed disease still face …

Background: Methadone has been associated with lower overall survival (OS) in patients
with chronic pain. There are no data available on the association of methadone with OS in …

Methadone is an effective and long-lasting analgesic drug that is also used in medication-
assisted treatment for people with opioid use disorders. Although there is evidence that …