The therapeutic properties of plants have been recognised since time immemorial. Many
pathological conditions have been treated using plant-derived medicines. These medicines …

Lung cancer is one of the most frequently diagnosed cancers and is the leading cause of
cancer-related death worldwide. Non-small-cell lung cancer (NSCLC), a heterogeneous …

Cancers remain a major public health problem worldwide, which still require profound
research in both the basic and preclinical fields. Patient-derived xenograft (PDX) models are …

Spleen tyrosine kinase (SYK) is known to have a crucial role in adaptive immune receptor
signalling. However, recent reports indicate that SYK also mediates other, unexpectedly …

Retinoblastoma is an aggressive childhood cancer of the developing retina that is initiated
by the biallelic loss of RB1. Tumours progress very quickly following RB1 inactivation but the …

The application of RNA interference (RNAi) to mammalian cells has provided the means to
perform phenotypic screens to determine the functions of genes. Although RNAi has …

Context In many cancers, specific subpopulations of cells appear to be uniquely capable of
initiating and maintaining tumors. The strongest support for this cancer stem cell model …

Spleen tyrosine kinase (Syk) is a cytoplasmic protein tyrosine kinase well known for its
ability to couple immune cell receptors to intracellular signaling pathways that regulate …

Hepatocellular carcinoma (HCC) is one of most lethal cancers worldwide. Strategic
decisions for the advancement of molecular therapies in this neoplasm require a clear …

SYK (spleen tyrosine kinase) is well-characterized in the immune system as an essential
enzyme required for signaling through multiple classes of immune recognition receptors. As …