Dynamic alternative DNA structures in biology and disease
G Wang, KM Vasquez - Nature Reviews Genetics, 2023 - nature.com
Repetitive elements in the human genome, once considered 'junk DNA', are now known to
adopt more than a dozen alternative (that is, non-B) DNA structures, such as self-annealed …
adopt more than a dozen alternative (that is, non-B) DNA structures, such as self-annealed …
Mechanisms of DNA damage, repair, and mutagenesis
N Chatterjee, GC Walker - Environmental and molecular …, 2017 - Wiley Online Library
Living organisms are continuously exposed to a myriad of DNA damaging agents that can
impact health and modulate disease‐states. However, robust DNA repair and damage …
impact health and modulate disease‐states. However, robust DNA repair and damage …
Metal complex interactions with DNA
Increasing numbers of DNA structures are being revealed using biophysical, spectroscopic
and genomic methods. The diversity of transition metal complexes is also growing, as the …
and genomic methods. The diversity of transition metal complexes is also growing, as the …
DNA interstrand crosslink repair and cancer
Interstrand crosslinks (ICLs) are highly toxic DNA lesions that prevent transcription and
replication by inhibiting DNA strand separation. Agents that induce ICLs were one of the …
replication by inhibiting DNA strand separation. Agents that induce ICLs were one of the …
DNA mismatch repair and its many roles in eukaryotic cells
D Liu, G Keijzers, LJ Rasmussen - Mutation Research/Reviews in Mutation …, 2017 - Elsevier
DNA mismatch repair (MMR) is an important DNA repair pathway that plays critical roles in
DNA replication fidelity, mutation avoidance and genome stability, all of which contribute …
DNA replication fidelity, mutation avoidance and genome stability, all of which contribute …
Advances in understanding the complex mechanisms of DNA interstrand cross-link repair
C Clauson, OD Schärer… - Cold Spring Harbor …, 2013 - cshperspectives.cshlp.org
DNA interstrand cross-links (ICLs) are lesions caused by a variety of endogenous
metabolites, environmental exposures, and cancer chemotherapeutic agents that have two …
metabolites, environmental exposures, and cancer chemotherapeutic agents that have two …
Non-B DNA structure-induced genetic instability and evolution
J Zhao, A Bacolla, G Wang, KM Vasquez - Cellular and molecular life …, 2010 - Springer
Repetitive DNA motifs are abundant in the genomes of various species and have the
capacity to adopt non-canonical (ie, non-B) DNA structures. Several non-B DNA structures …
capacity to adopt non-canonical (ie, non-B) DNA structures. Several non-B DNA structures …
FAN1 modifies Huntington's disease progression by stabilizing the expanded HTT CAG repeat
R Goold, M Flower, DH Moss, C Medway… - Human molecular …, 2019 - academic.oup.com
Huntington's disease (HD) is an inherited neurodegenerative disease caused by an
expanded CAG repeat in the huntingtin (HTT) gene. CAG repeat length explains around half …
expanded CAG repeat in the huntingtin (HTT) gene. CAG repeat length explains around half …
Repair of cisplatin-induced DNA interstrand crosslinks by a replication-independent pathway involving transcription-coupled repair and translesion synthesis
M Enoiu, J Jiricny, OD Schärer - Nucleic acids research, 2012 - academic.oup.com
DNA interstrand crosslinks (ICLs) formed by antitumor agents, such as cisplatin or mitomycin
C, are highly cytotoxic DNA lesions. Their repair is believed to be triggered primarily by the …
C, are highly cytotoxic DNA lesions. Their repair is believed to be triggered primarily by the …
Impact of alternative DNA structures on DNA damage, DNA repair, and genetic instability
G Wang, KM Vasquez - DNA repair, 2014 - Elsevier
Repetitive genomic sequences can adopt a number of alternative DNA structures that differ
from the canonical B-form duplex (ie non-B DNA). These non-B DNA-forming sequences …
from the canonical B-form duplex (ie non-B DNA). These non-B DNA-forming sequences …