Thiazole derivatives in medicinal chemistry: Recent advancements in synthetic strategies, structure activity relationship and pharmacological outcomes
Thiazole derivatives remains honored heterocycles in the field of medicinal chemistry. This
scaffold has been proven as a universal motif that is present in numerous pharmacologically …
scaffold has been proven as a universal motif that is present in numerous pharmacologically …
[HTML][HTML] Small molecules containing chalcogen elements (S, Se, Te) as new warhead to fight neglected tropical diseases
A Henriquez-Figuereo, C Morán-Serradilla… - European Journal of …, 2023 - Elsevier
Neglected tropical diseases (NTDs) encompass a group of infectious diseases with a
protozoan etiology, high incidence, and prevalence in developing countries. As a result …
protozoan etiology, high incidence, and prevalence in developing countries. As a result …
Synthetic and medicinal perspective of antileishmanial agents: an overview
S Pawar, MK Kumawat, M Kundu, K Kumar - Journal of Molecular Structure, 2023 - Elsevier
Leishmaniasis is one of the most common neglected tropical diseases (NTD), and is
originated in over 98 countries, affecting about 12 million people every year, which is …
originated in over 98 countries, affecting about 12 million people every year, which is …
N-substituted-4-(pyridin-4-ylalkyl) piperazine-1-carboxamides and related compounds as Leishmania CYP51 and CYP5122A1 inhibitors
CYP5122A1, an enzyme involved in sterol biosynthesis in Leishmania, was recently
characterized as a sterol C4-methyl oxidase. Screening of a library of compounds against …
characterized as a sterol C4-methyl oxidase. Screening of a library of compounds against …
Transport of Molecular Cargo by Interaction with Virus‐Like Particle RNA
Virus‐like particles (VLPs) derived from Leviviridae virions contain substantial amounts of
cellular and plasmid‐derived RNA. This encapsidated polynucleotide serves as a reservoir …
cellular and plasmid‐derived RNA. This encapsidated polynucleotide serves as a reservoir …
Functional Cyanine‐Based PVA: PVP Polymers as Antimicrobial Tools toward Food and Health‐Care Bacterial Infections
GA Marcelo, J Galhano, MP Duarte… - Macromolecular …, 2022 - Wiley Online Library
The rising of multidrug‐resistant bacteria and their associated proliferation as harmful
microorganisms boosts the creation of new antibacterial surfaces and biomaterials with …
microorganisms boosts the creation of new antibacterial surfaces and biomaterials with …
Classical thiazole orange and its regioisomer as fluorogenic probes for nucleolar RNA imaging in living cells
M He, Y Sato, S Nishizawa - Analyst, 2023 - pubs.rsc.org
In contrast to well-established DNA-selective dyes for live cell imaging, RNA-selective dyes
have been less developed owing to the challenges of making small molecules have RNA …
have been less developed owing to the challenges of making small molecules have RNA …
Evolution of the Quinoline Scaffold for the Treatment of Leishmaniasis: A Structural Perspective
CFM Silva, DCGA Pinto, PA Fernandes, AMS Silva - Pharmaceuticals, 2024 - mdpi.com
Since the beginning of the XXI century, Leishmaniasis has been integrated into the World
Health Organization's list of the 20 neglected tropical diseases, being considered a public …
Health Organization's list of the 20 neglected tropical diseases, being considered a public …
Synthesis, structure, biological/chemosensor evaluation and molecular docking studies of aminobenzothiazole Schiff bases
JK Suyambulingam, R Karvembu… - Journal of Adhesion …, 2020 - Taylor & Francis
Two Schiff bases derived from aminobenzothiazole derivatives with Salicylaldehyde/
Bromosalicylaldehyde namely 2-[6-Methylbenzothiazol-2-ylimino) methyl phenol (1) and 3 …
Bromosalicylaldehyde namely 2-[6-Methylbenzothiazol-2-ylimino) methyl phenol (1) and 3 …
Some scaffolds as anti-leishmanial agents: A review
T Mahender, W Pankaj, SP Kumar… - Mini reviews in …, 2022 - ingentaconnect.com
Leishmaniasis is a parasitic infectious neglected tropical disease transmitted to humans by
the parasites of Leishmania species. Mainly, three types of leishmaniases are usually …
the parasites of Leishmania species. Mainly, three types of leishmaniases are usually …