Purpose Functional status and chronic health status are important baseline characteristics of
critically ill patients. The assessment of frailty on admission to the intensive care unit (ICU) …

With ageing, the potency of individual risk factors traditionally associated with common
illnesses declines. Instead, it is becoming clear that the impact of a wide range of age …

The concept of healthspan is relatively new in geroscience research, which seeks to
understand the biological mechanisms of aging (Burch et al. 2014; Sierra and Kohanski …

Background Frailty is a key determinant of clinical outcomes. We sought to describe frailty
among US Veterans and its association with mortality. Methods Nationwide retrospective …

A frailty index (FI) based entirely on common clinical and laboratory tests might offer
scientific advantages in understanding ageing and pragmatic advantages in screening. Our …

Background The trajectory of frailty in older adults is important to public health; therefore,
markers that may help predict this and other important outcomes could be beneficial …

Background Frailty is a customized marker of biological age that helps to gauge an
individual's functional physiologic reserve and ability to react to stress and is associated with …

Background Frailty is a risk factor for cardiovascular disease (CVD). Underlying mechanisms
to explain the connection between frailty and CVD are unclear. We sought to examine the …

To explore the mechanistic relationships between aging, frailty and mortality, we developed
a computational model in which possible health attributes are represented by the nodes of a …

Background The Short Physical Performance Battery (SPPB) is an inexpensive, reliable, and
easy‐to‐implement measure of lower‐extremity physical function. Strong evidence links …