Streptococcus pneumoniae has a complex relationship with its obligate human host. On the
one hand, the pneumococci are highly adapted commensals, and their main reservoir on the …

The paucity of blood granulocyte populations such as neutrophils in laboratory mice is a
notable difference between this model organism and humans, but the cause of this species …

Epidemiological observations and animal models have long shown synergy between
influenza virus infections and bacterial infections. Influenza virus infection leads to an …

Streptococcus pneumoniae (also called pneumococcus) is not only a commensal that
frequently colonizes the human upper respiratory tract but also a pathogen that causes …

Host-to-host transmission is a critical step for infection. Here we studied transmission of the
opportunistic pathogen Streptococcus pneumoniae in an infant mouse model. Transmission …

The past two decades have witnessed an alarming expansion of staphylococcal disease
caused by community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) …

Abstract Vaccines targeting Streptococcus pneumoniae (Spn) are limited by dependence on
capsular polysaccharide and its serotype diversity. More broadly-based approaches using …

Successful colonization of a host requires bacterial adaptation through genetic and
population changes that are incompletely defined. Using chromosomal barcoding and high …

The capacity of Streptococcus pneumoniae to successfully transmit and colonize new
human hosts is a critical aspect of pneumococcal population biology and a prerequisite for …

Small animal models have been a challenge for the study of SARS-CoV-2 transmission, with
most investigators using golden hamsters or ferrets. Mice have the advantages of low cost …