Advances in sequencing and high-throughput techniques have provided an unprecedented
opportunity to interrogate human diseases on a genome-wide scale. The list of disease …

Platelets are abundant, small, anucleate circulating cells, serving many emerging
pathophysiological roles beyond hemostasis; including active critical roles in thrombosis …

Next-generation DNA sequencing promises to revolutionize clinical medicine and basic
research. However, while this technology has the capacity to generate hundreds of billions …

As the primary cellular location for respiration and energy production, mitochondria serve in
a critical capacity to the cell. Yet, by virtue of this very function of respiration, mitochondria …

Mitochondrial DNA (mtDNA) is believed to be highly vulnerable to age-associated damage
and mutagenesis by reactive oxygen species (ROS). However, somatic mtDNA mutations …

The use of molecular taxonomy for identifying recently diverged species has transformed the
study of speciation in fungi. The pathogenic fungus Paracoccidioides spp has been …

Redox homeostasis is a delicate balancing act of maintaining appropriate levels of
antioxidant defense mechanisms and reactive oxidizing oxygen and nitrogen species. Any …

Intracellular concentrations of the four deoxyribonucleoside triphosphates (dNTPs) are
closely regulated, and imbalances in the four dNTP pools have genotoxic consequences …

How mitochondria process DNA damage and whether a change in the steady-state level of
mitochondrial DNA damage (mtDNA) contributes to mitochondrial dysfunction are questions …

DNA polymerases are indispensable for maintaining the integrity of the genome, both
through faithful replication of DNA and by repairing damage to DNA. Among the 16 highly …