FIG. 1. Schematic representation of the MPRs. 0, N-linked glycosylation 13 of the CI-MPR
represents the region that is similar to the type I1 repeats of fibronectin. Modified from Ref …

A prominent feature of brain pathology in Alzheimer's disease is a robust activation of the
neuronal lysosomal system and major cellular pathways converging on the lysosome …

The early endosome is the first vacuolar compartment along the endocytic pathway. It is the
site of internalization and initial processing of amyloid precursor protein (APP) and …

The serine proteinase granzyme B is crucial for the rapid induction of target cell apoptosis by
cytotoxic T cells. Granzyme B was recently demonstrated to enter cells in a perforin …

The two members of the P-type lectin family, the cation-dependent mannose 6-phosphate
receptor (CD-MPR) and the insulin-like growth factor II/mannose 6-phosphate receptor (IGF …

Stable BHK cell lines inducibly expressing wild-type or dominant negative mutant forms of
the rab7 GTPase were isolated and used to analyze the role of a rab7-regulated pathway in …

Salmonella typhimurium is an intracellular bacterial pathogen that remains enclosed in
vacuoles (SCV) upon entry into the host cell. In this study we have examined the intracellular …

Mannose 6-phosphate-dependent transport of soluble lysosomal enzymes is a crucial step
in the biogenesis of lysosomes. Newly synthesized lysosomal enzymes are carried from …

We have cloned and sequenced the full-length cDNA for the human cation-independent
mannose 6-phosphate receptor from four overlapping clones. The 9104-nucleotide …

The mannose 6-phosphate/insulin-like growth factor-II (Man-6-P/IGF-II) receptor is known to
cycle between the Golgi, endosomes, and the plasma membrane. In the Golgi the receptor …