Bidirectional learning in upbound and downbound microzones of the cerebellum

CI De Zeeuw - Nature Reviews Neuroscience, 2021 - nature.com
Over the past several decades, theories about cerebellar learning have evolved. A relatively
simple view that highlighted the contribution of one major form of heterosynaptic plasticity to …

Regional functionality of the cerebellum

L Witter, CI De Zeeuw - Current opinion in neurobiology, 2015 - Elsevier
Highlights•The cerebellum contains zones with different levels of intrinsic
activity.•Modulation of activity in cerebellar modules is dictated by inputs.•Activities can differ …

Cerebellum-specific deletion of the GABAA receptor δ subunit leads to sex-specific disruption of behavior

S Rudolph, C Guo, SL Pashkovski, T Osorno, WF Gillis… - Cell Reports, 2020 - cell.com
Granule cells (GCs) of the cerebellar input layer express high-affinity δ GABA A subunit-
containing GABA A receptors (δGABA A Rs) that respond to ambient GABA levels and …

Task-dependent optimal representations for cerebellar learning

M Xie, SP Muscinelli, KD Harris, A Litwin-Kumar - Elife, 2023 - elifesciences.org
The cerebellar granule cell layer has inspired numerous theoretical models of neural
representations that support learned behaviors, beginning with the work of Marr and Albus …

In vivo whole-cell patch-clamp methods: recent technical progress and future perspectives

A Noguchi, Y Ikegaya, N Matsumoto - Sensors, 2021 - mdpi.com
Brain functions are fundamental for the survival of organisms, and they are supported by
neural circuits consisting of a variety of neurons. To investigate the function of neurons at the …

Cerebellar Purkinje cells control eye movements with a rapid rate code that is invariant to spike irregularity

HL Payne, RL French, CC Guo, TDB Nguyen-Vu… - Elife, 2019 - elifesciences.org
The rate and temporal pattern of neural spiking each have the potential to influence
computation. In the cerebellum, it has been hypothesized that the irregularity of interspike …

Human Purkinje cells outperform mouse Purkinje cells in dendritic complexity and computational capacity

S Masoli, D Sanchez-Ponce, N Vrieler… - Communications …, 2024 - nature.com
Purkinje cells in the cerebellum are among the largest neurons in the brain and have been
extensively investigated in rodents. However, their morphological and physiological …

Gradients in the mammalian cerebellar cortex enable Fourier-like transformation and improve storing capacity

I Straub, L Witter, A Eshra, M Hoidis, N Byczkowicz… - Elife, 2020 - elifesciences.org
Cerebellar granule cells (GCs) make up the majority of all neurons in the vertebrate brain,
but heterogeneities among GCs and potential functional consequences are poorly …

Facilitation of mossy fibre‐driven spiking in the cerebellar nuclei by the synchrony of inhibition

Y Wu, IM Raman - The Journal of physiology, 2017 - Wiley Online Library
Key points Large premotor neurons of the cerebellar nuclei (CbN cells) integrate synaptic
inhibition from Purkinje neurons and synaptic excitation from mossy fibres to generate …

Whole-Cell Properties of Cerebellar Nuclei Neurons In Vivo

CB Canto, L Witter, CI De Zeeuw - PloS one, 2016 - journals.plos.org
Cerebellar nuclei neurons integrate sensorimotor information and form the final output of the
cerebellum, projecting to premotor brainstem targets. This implies that, in contrast to …