Bidirectional learning in upbound and downbound microzones of the cerebellum
CI De Zeeuw - Nature Reviews Neuroscience, 2021 - nature.com
Over the past several decades, theories about cerebellar learning have evolved. A relatively
simple view that highlighted the contribution of one major form of heterosynaptic plasticity to …
simple view that highlighted the contribution of one major form of heterosynaptic plasticity to …
Regional functionality of the cerebellum
L Witter, CI De Zeeuw - Current opinion in neurobiology, 2015 - Elsevier
Highlights•The cerebellum contains zones with different levels of intrinsic
activity.•Modulation of activity in cerebellar modules is dictated by inputs.•Activities can differ …
activity.•Modulation of activity in cerebellar modules is dictated by inputs.•Activities can differ …
Cerebellum-specific deletion of the GABAA receptor δ subunit leads to sex-specific disruption of behavior
Granule cells (GCs) of the cerebellar input layer express high-affinity δ GABA A subunit-
containing GABA A receptors (δGABA A Rs) that respond to ambient GABA levels and …
containing GABA A receptors (δGABA A Rs) that respond to ambient GABA levels and …
Task-dependent optimal representations for cerebellar learning
The cerebellar granule cell layer has inspired numerous theoretical models of neural
representations that support learned behaviors, beginning with the work of Marr and Albus …
representations that support learned behaviors, beginning with the work of Marr and Albus …
In vivo whole-cell patch-clamp methods: recent technical progress and future perspectives
Brain functions are fundamental for the survival of organisms, and they are supported by
neural circuits consisting of a variety of neurons. To investigate the function of neurons at the …
neural circuits consisting of a variety of neurons. To investigate the function of neurons at the …
Cerebellar Purkinje cells control eye movements with a rapid rate code that is invariant to spike irregularity
The rate and temporal pattern of neural spiking each have the potential to influence
computation. In the cerebellum, it has been hypothesized that the irregularity of interspike …
computation. In the cerebellum, it has been hypothesized that the irregularity of interspike …
Human Purkinje cells outperform mouse Purkinje cells in dendritic complexity and computational capacity
Purkinje cells in the cerebellum are among the largest neurons in the brain and have been
extensively investigated in rodents. However, their morphological and physiological …
extensively investigated in rodents. However, their morphological and physiological …
Gradients in the mammalian cerebellar cortex enable Fourier-like transformation and improve storing capacity
I Straub, L Witter, A Eshra, M Hoidis, N Byczkowicz… - Elife, 2020 - elifesciences.org
Cerebellar granule cells (GCs) make up the majority of all neurons in the vertebrate brain,
but heterogeneities among GCs and potential functional consequences are poorly …
but heterogeneities among GCs and potential functional consequences are poorly …
Facilitation of mossy fibre‐driven spiking in the cerebellar nuclei by the synchrony of inhibition
Y Wu, IM Raman - The Journal of physiology, 2017 - Wiley Online Library
Key points Large premotor neurons of the cerebellar nuclei (CbN cells) integrate synaptic
inhibition from Purkinje neurons and synaptic excitation from mossy fibres to generate …
inhibition from Purkinje neurons and synaptic excitation from mossy fibres to generate …
Whole-Cell Properties of Cerebellar Nuclei Neurons In Vivo
Cerebellar nuclei neurons integrate sensorimotor information and form the final output of the
cerebellum, projecting to premotor brainstem targets. This implies that, in contrast to …
cerebellum, projecting to premotor brainstem targets. This implies that, in contrast to …