Lupus nephritis is an immune complex GN that develops as a frequent complication of SLE.
The pathogenesis of lupus nephritis involves a variety of pathogenic mechanisms. The …

Macrophages are found in normal kidney and in increased numbers in diseased kidney,
where they act as key players in renal injury, inflammation, and fibrosis. Macrophages are …

Objectives While various monocyte chemokine systems are increased in expression in
osteoarthritis (OA), the hierarchy of chemokines and chemokine receptors in mediating …

Monocytes undergo phenotypic and functional changes in response to inflammatory cues,
but the molecular signals that drive different monocyte states remain largely undefined. We …

Monocyte chemoattractant protein-1 and the kidney : Current Opinion in Nephrology and
Hypertension Monocyte chemoattractant protein-1 and the kidney : Current Opinion in …

Inflammation is a key characteristic of kidney disease, but this immune response is two-
faced. In the acute phase of kidney injury, there is an activation of the immune cells to fight …

Renal dendritic cells (DCs) and macrophages represent a constitutive, extensive and
contiguous network of innate immune cells that provide sentinel and immune-intelligence …

Immunotherapies have shown considerable efficacy for the treatment of various cancers, but
a multitude of patients remain unresponsive for various reasons, including poor homing of T …

Lupus nephritis (LN) is a serious complication of systemic lupus erythematosus (SLE) that
occurs in about half of patients. LN is characterized by glomerular deposition of immune …

The monocyte chemoattractant protein CCL2 is crucial for monocyte and T cell recruitment
from the vascular to the extravascular compartment at sites of inflammation. CCL2 is …