Histone methylation is a key posttranslational modification of chromatin, and its
dysregulation affects a wide array of nuclear activities including the maintenance of genome …

The precise regulation of gene transcription is required to establish and maintain cell type-
specific gene expression programs during multicellular development. In addition to …

Lysine-specific demethylase 5A (KDM5A, also named RBP2 or JARID1A) is a demethylase
that can remove methyl groups from histones H3K4me1/2/3. It is aberrantly expressed in …

Histone methylation, one of the most common histone modifications, has fundamental roles
in regulating chromatin-based processes. Jumonji histone lysine demethylases (JMJC …

Highlights•Intrinsic disorder empowers histone tails' diverse roles in chromatin
signaling.•Introducing PTMs and histone variants dramatically enhances the functional …

Autism spectrum disorder (ASD) is a constellation of neurodevelopmental disorders with
high phenotypic and genetic heterogeneity, complicating the discovery of causative genes …

Epigenetic regulation of gene expression is crucial to the determination of cell fate in
development and differentiation, and the Polycomb (PcG) and Trithorax (TrxG) groups of …

Simple Summary Aberrations in epigenetic modulators have been widely identified in
cancer; therefore, these modulators are attractive targets for cancer treatment. KDM5 is an …

Mammalian histone demethylases of the KDM5 family are mediators of gene expression
dynamics during developmental, cellular differentiation, and other nuclear processes. They …

Conventional understanding of how enzymes function strongly emphasizes the role of
structure. However, increasing evidence clearly indicates that enzymes do not remain fixed …