The emerging role of KDM5A in human cancer
GJ Yang, MH Zhu, XJ Lu, YJ Liu, JF Lu… - Journal of hematology & …, 2021 - Springer
Histone methylation is a key posttranslational modification of chromatin, and its
dysregulation affects a wide array of nuclear activities including the maintenance of genome …
dysregulation affects a wide array of nuclear activities including the maintenance of genome …
[HTML][HTML] Understanding the interplay between CpG island-associated gene promoters and H3K4 methylation
The precise regulation of gene transcription is required to establish and maintain cell type-
specific gene expression programs during multicellular development. In addition to …
specific gene expression programs during multicellular development. In addition to …
Pharmacological inhibition of KDM5A for cancer treatment
Lysine-specific demethylase 5A (KDM5A, also named RBP2 or JARID1A) is a demethylase
that can remove methyl groups from histones H3K4me1/2/3. It is aberrantly expressed in …
that can remove methyl groups from histones H3K4me1/2/3. It is aberrantly expressed in …
[HTML][HTML] Recent developments in catalysis and inhibition of the Jumonji histone demethylases
L Sarah, DG Fujimori - Current opinion in structural biology, 2023 - Elsevier
Histone methylation, one of the most common histone modifications, has fundamental roles
in regulating chromatin-based processes. Jumonji histone lysine demethylases (JMJC …
in regulating chromatin-based processes. Jumonji histone lysine demethylases (JMJC …
Histone tails as signaling antennas of chromatin
Highlights•Intrinsic disorder empowers histone tails' diverse roles in chromatin
signaling.•Introducing PTMs and histone variants dramatically enhances the functional …
signaling.•Introducing PTMs and histone variants dramatically enhances the functional …
KDM5A mutations identified in autism spectrum disorder using forward genetics
L El Hayek, IO Tuncay, N Nijem, J Russell, S Ludwig… - Elife, 2020 - elifesciences.org
Autism spectrum disorder (ASD) is a constellation of neurodevelopmental disorders with
high phenotypic and genetic heterogeneity, complicating the discovery of causative genes …
high phenotypic and genetic heterogeneity, complicating the discovery of causative genes …
Histone methylases and demethylases regulating antagonistic methyl marks: changes occurring in cancer
J Taylor-Papadimitriou, JM Burchell - Cells, 2022 - mdpi.com
Epigenetic regulation of gene expression is crucial to the determination of cell fate in
development and differentiation, and the Polycomb (PcG) and Trithorax (TrxG) groups of …
development and differentiation, and the Polycomb (PcG) and Trithorax (TrxG) groups of …
Diverse functions of KDM5 in cancer: Transcriptional repressor or activator?
Y Ohguchi, H Ohguchi - Cancers, 2022 - mdpi.com
Simple Summary Aberrations in epigenetic modulators have been widely identified in
cancer; therefore, these modulators are attractive targets for cancer treatment. KDM5 is an …
cancer; therefore, these modulators are attractive targets for cancer treatment. KDM5 is an …
Functions and interactions of mammalian KDM5 demethylases
E Pavlenko, T Ruengeler, P Engel, S Poepsel - Frontiers in genetics, 2022 - frontiersin.org
Mammalian histone demethylases of the KDM5 family are mediators of gene expression
dynamics during developmental, cellular differentiation, and other nuclear processes. They …
dynamics during developmental, cellular differentiation, and other nuclear processes. They …
Enzyme dynamics: Looking beyond a single structure
Conventional understanding of how enzymes function strongly emphasizes the role of
structure. However, increasing evidence clearly indicates that enzymes do not remain fixed …
structure. However, increasing evidence clearly indicates that enzymes do not remain fixed …