From sites of transcription in the nucleus to the outreaches of the cytoplasm, messenger
RNAs are associated with RNA-binding proteins. These proteins influence pre-mRNA …

Evolution of exon-intron structure of eukaryotic genes has been a matter of long-standing,
intensive debate. The introns-early concept, later rebranded 'introns first'held that protein …

The essential yeast proteins Yra1 and Sub2 are messenger RNA export factors that have
conserved counterparts in metazoans, designated Aly and UAP56, respectively,,,,,,. These …

RNA helicases from the DEAD-box family are found in almost all organisms and have
important roles in RNA metabolism. They are associated with many processes ranging from …

Gene expression in eukaryotes requires several multi-component cellular machines. Each
machine carries out a separate step in the gene expression pathway, which includes …

DEAD-box ATPases constitute a very large protein family present in all cells, often in great
abundance. From bacteria to humans, they play critical roles in many aspects of RNA …

The only mammalian RNA binding adapter proteins known to partner with TAP/NXF1, the
primary receptor for general mRNA export, are members of the REF family. We demonstrate …

Messenger RNAs (mRNAs) are at the center of the central dogma of molecular biology. In
eukaryotic cells, these long ribonucleic acid polymers do not exist as naked transcripts; …

In eukaryotic cells, the enclosure of the genetic information in the nucleus allows the spatial
and temporal separation of DNA replication and transcription from cytoplasmic protein …

ABSTRACT DEAD-box proteins are characterized by nine conserved motifs. According to
these criteria, several hundreds of these proteins can be identified in databases. Many …