Dysregulated cell division, which leads to aberrant cell proliferation, is one of the key
hallmarks of cancer. Therefore, therapeutic targets that block cell division would be effective …

Abstract Cyclin-dependent kinase 7 (CDK7), along with cyclin H and MAT1, forms the CDK-
activating complex (CAK), which directs progression through the cell cycle via T-loop …

The MYC oncoproteins are thought to stimulate tumor cell growth and proliferation through
amplification of gene transcription, a mechanism that has thwarted most efforts to inhibit …

Abnormal activity of the core cell-cycle machinery is seen in essentially all tumor types and
represents a driving force of tumorigenesis. Recent studies revealed that cell-cycle proteins …

The roles of RNA 5-methylcytosine (RNA: m5C) and RNA: m5C methyltransferases (RCMTs)
in lineage-associated chromatin organization and drug response/resistance are unclear …

Drugs that inhibit estrogen receptor-α (ER) activity have been highly successful in treating
and reducing breast cancer progression in ER-positive disease. However, resistance to …

Summary Cyclin-dependent kinase 7 (CDK7) regulates both cell cycle and transcription, but
its precise role remains elusive. We previously described THZ1, a CDK7 inhibitor, which …

Cyclin-dependent kinase-2 (CDK2) is a member of protein kinase family. It plays an
important role in regulating various events of eukaryotic cell division cycle. Accumulated …

Concerted multidisciplinary efforts have led to the development of Cyclin-Dependent Kinase
inhibitors (CDKi's) as small molecule drugs and chemical probes of intracellular CDK …

The serine/threonine protein kinases CDK2 and GSK-3β are key oncotargets in breast
cancer cell lines, therefore, in the present study three series of oxindole-benzofuran hybrids …