Cytokines affect nearly every biological process; these include embryonic development,
disease pathogenesis, non‐specific response to infection, specific response to antigen …

Abstract Alpha‐1 antitrypsin (AAT) deficiency is an under‐recognized hereditary disorder
associated with the premature onset of chronic obstructive pulmonary disease, liver cirrhosis …

The rationale of α1-antitrypsin (AAT) augmentation therapy to treat progressive emphysema
in AAT-deficient patients is based on inhibition of neutrophil elastase; however, the benefit of …

Summary Alpha-1 antitrypsin deficiency (AATD) arises from mutations in the SERPINA1
gene encoding alpha-1 antitrypsin (AAT) that lead to AAT retention in the endoplasmic …

Emphysema is one manifestation of a group of chronic, obstructive, and frequently
progressive destructive lung diseases. Cigarette smoking and air pollution are the main …

At present, proven clinical treatments but no cures are available for diabetes, a global
epidemic with a huge economic burden. Transplantation of islets of Langerhans by their …

Pathological inflammation and autoimmune disease frequently involve elevated neutrophil
activity in the absence of infectious agents. Tumor necrosis factor–α (TNF-α) contributes to …

Alpha-1 antitrypsin (AAT) is the canonical serine protease inhibitor of neutrophil-derived
proteases and can modulate innate immune mechanisms through its anti-inflammatory …

The recent development of small-molecule tyrosine kinase (TK) inhibitors offers increasing
opportunities for the treatment of autoimmune diseases. In this study, we investigated the …

Several observations suggest endogenous suppressors of inflammatory mediators are
present in human blood. α-1-Antitrypsin (AAT) is the most abundant serine protease inhibitor …