The division of medulloblastoma into different subgroups by microarray expression profiling
has dramatically changed our perspective of this malignant childhood brain tumour. Now …

The fourth edition of the World Health Organization (WHO) classification of tumours of the
central nervous system, published in 2007, lists several new entities, including angiocentric …

Nanomaterials offer new opportunities for cancer diagnosis and treatment. Multifunctional
nanoparticles harboring various functions including targeting, imaging, therapy, and etc …

Malignant brain tumours continue to be the cause of a disproportionate level of morbidity
and mortality across a wide range of individuals. The most common variants in the adult and …

Pluripotency of embryonic stem cells (ESCs) and induced pluripotent stem cells is regulated
by a well characterized gene transcription circuitry. The circuitry is assembled by ESC …

Radiotherapy represents the most effective nonsurgical treatments for gliomas. However,
gliomas are highly radioresistant and recurrence is nearly universal. Results from our …

Cancer stem cells are rare tumor cells characterized by their ability to self-renew and to
induce tumorigenesis. They are present in gliomas and may be responsible for the lethality …

Cancer stem cells (CSCs) are thought to be critical for the engraftment and long-term growth
of many tumors, including glioblastoma (GBM). The cells are at least partially spared by …

The concept that some childhood malignancies arise from postnatally persistent embryonal
cells has a long history. Recent research has strengthened the links between driver …

Signals through the Notch receptors are used throughout development to control cellular
fate choices. Loss-and gain-of-function studies revealed both the pleiotropic action of the …