It has been a decade since it was discovered that primary cilia have an essential role in
Hedgehog (Hh) signaling in mammals. This discovery came from screens in the mouse that …

The Hedgehog (HH) signaling pathway was discovered originally as a key pathway in
embryonic patterning and development. Since its discovery, it has become increasingly …

In vertebrates, sterols are necessary for Hedgehog signaling, a pathway critical in
embryogenesis and cancer. Sterols activate the membrane protein Smoothened by binding …

Hedgehog proteins constitute one of a small number of families of secreted signals that have
a central role in the development of metazoans. Genetic analyses in flies, fish and mice have …

Hedgehog (Hh) proteins regulate the development of a wide range of metazoan embryonic
and adult structures, and disruption of Hh signaling pathways results in various human …

Most monogenic cases of obesity in humans have been linked to mutations in genes
encoding members of the leptin–melanocortin pathway. Specifically, mutations in MC4R, the …

Oxysterols bind the seven-transmembrane protein Smo (Smo) and potently activate
vertebrate Hedgehog (Hh) signaling, a pathway essential in embryonic development, adult …

Mammalian Sonic hedgehog (Shh) signaling is essential for embryonic development and
stem cell maintenance and has critical roles in tumorigenesis. Although core components of …

The primary cilium is a cellular organelle that is almost ubiquitous in eukaryotes, yet its
functions in vertebrates have been slow to emerge. The last fifteen years have been marked …

Hedgehog (Hh) signaling during development and in postembryonic tissues requires
activation of the 7TM oncoprotein Smoothened (Smo) by mechanisms that may involve …