Cancer vaccines: the next immunotherapy frontier

MJ Lin, J Svensson-Arvelund, GS Lubitz, A Marabelle… - Nature cancer, 2022 - nature.com
After several decades, therapeutic cancer vaccines now show signs of efficacy and potential
to help patients resistant to other standard-of-care immunotherapies, but they have yet to …

Diffuse large B-cell lymphoma

LH Sehn, G Salles - New England Journal of Medicine, 2021 - Mass Medical Soc
Diffuse Large B-Cell Lymphoma DLBCL, an aggressive cancer, accounts for about 30% of
all lymphomas. Empirical combination chemotherapy cures about 65% of patients initially …

[HTML][HTML] Polatuzumab vedotin in previously untreated diffuse large B-cell lymphoma

H Tilly, F Morschhauser, LH Sehn… - … England Journal of …, 2022 - Mass Medical Soc
Background Diffuse large B-cell lymphoma (DLBCL) is typically treated with rituximab,
cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP). However, only 60 …

Atorvastatin for anthracycline-associated cardiac dysfunction: the STOP-CA randomized clinical trial

TG Neilan, T Quinaglia, T Onoue, SS Mahmood… - Jama, 2023 - jamanetwork.com
Importance Anthracyclines treat a broad range of cancers. Basic and retrospective clinical
data have suggested that use of atorvastatin may be associated with a reduction in cardiac …

[HTML][HTML] Association of clinical factors and recent anticancer therapy with COVID-19 severity among patients with cancer: a report from the COVID-19 and Cancer …

P Grivas, AR Khaki, TM Wise-Draper, B French… - Annals of oncology, 2021 - Elsevier
Background Patients with cancer may be at high risk of adverse outcomes from severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We analyzed a cohort of …

Polatuzumab vedotin in relapsed or refractory diffuse large B-cell lymphoma

LH Sehn, AF Herrera, CR Flowers… - Journal of Clinical …, 2020 - ascopubs.org
PURPOSE Patients with transplantation-ineligible relapsed/refractory (R/R) diffuse large B-
cell lymphoma (DLBCL) fare poorly, with limited treatment options. The antibody-drug …

[HTML][HTML] Tisagenlecleucel in adult relapsed or refractory diffuse large B-cell lymphoma

SJ Schuster, MR Bishop, CS Tam… - … England Journal of …, 2019 - Mass Medical Soc
Background Patients with diffuse large B-cell lymphoma that is refractory to primary and
second-line therapies or that has relapsed after stem-cell transplantation have a poor …

ROBUST: a phase III study of lenalidomide plus R-CHOP versus placebo plus R-CHOP in previously untreated patients with ABC-type diffuse large B-cell lymphoma

GS Nowakowski, A Chiappella… - Journal of Clinical …, 2021 - ascopubs.org
PURPOSE Patients with the activated B-cell-like (ABC) subtype of diffuse large B-cell
lymphoma (DLBCL) historically showed inferior survival with standard rituximab plus …

Evolution of cancer pharmacological treatments at the turn of the third millennium

L Falzone, S Salomone, M Libra - Frontiers in pharmacology, 2018 - frontiersin.org
The medical history of cancer began millennia ago. Historical findings of patients with
cancer date back to ancient Egyptian and Greek civilizations, where this disease was …

Targeted sequencing in DLBCL, molecular subtypes, and outcomes: a Haematological Malignancy Research Network report

SE Lacy, SL Barrans, PA Beer, D Painter… - Blood, The Journal …, 2020 - ashpublications.org
Based on the profile of genetic alterations occurring in tumor samples from selected diffuse
large B-cell lymphoma (DLBCL) patients, 2 recent whole-exome sequencing studies …