Apart from having been used and misused for at least four millennia for, among others,
recreational and medicinal purposes, the cannabis plant and its most peculiar chemical …

The endocannabinoid system (ECS) is composed of two G protein-coupled receptors
(GPCRs), the cannabinoid CB1 and CB2 receptors, and the two main endogenous lipid …

Most neurodegenerative disorders (NDD s) are characterized by cognitive impairment and
other neurological defects. The definite cause of and pathways underlying the progression …

As a consequence of an increasingly aging population, the number of people affected by
neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease and …

Recent years have yielded significant advances in our understanding of microglia, the
immune cells of the central nervous system (CNS). Microglia are key players in CNS …

Inflammation is an important pathogenic factor in Parkinson's disease (PD), so that it can
contribute to kill dopaminergic neurons of the substantia nigra and to enhance the …

As the resident immune cells in the central nervous system, microglia have long been
hypothesised to promote neuroinflammation and exacerbate neurotoxicity. However, this …

Cannabinoids form a singular family of plant-derived compounds (phytocannabinoids),
endogenous signaling lipids (endocannabinoids), and synthetic derivatives with multiple …

This review focuses on the role of the endocannabinoid signaling system in controlling
neuronal survival, an extremely important issue to be considered when developing new …

There are two well characterized cannabinoid receptors (CBRs), CB1-Rs and CB2-Rs, with
other candidates, such as GPR55, PPARs and vanilloid TRPV1 (VR1) receptors, which are …