The role of reactive oxygen species in arsenic toxicity

Y Hu, J Li, B Lou, R Wu, G Wang, C Lu, H Wang, J Pi… - Biomolecules, 2020 - mdpi.com
Arsenic poisoning is a global health problem. Chronic exposure to arsenic has been
associated with the development of a wide range of diseases and health problems in …

[HTML][HTML] Mitochondrial calcium transport and the redox nature of the calcium-induced membrane permeability transition

AE Vercesi, RF Castilho, AJ Kowaltowski… - Free Radical Biology …, 2018 - Elsevier
Mitochondria possess a Ca 2+ transport system composed of separate Ca 2+ influx and
efflux pathways. Intramitochondrial Ca 2+ concentrations regulate oxidative …

The mitochondrial permeability transition: nexus of aging, disease and longevity

H Rottenberg, JB Hoek - Cells, 2021 - mdpi.com
The activity of the mitochondrial permeability transition pore, mPTP, a highly regulated multi-
component mega-channel, is enhanced in aging and in aging-driven degenerative …

Arsenite induces testicular oxidative stress in vivo and in vitro leading to ferroptosis

P Meng, S Zhang, X Jiang, S Cheng, J Zhang… - Ecotoxicology and …, 2020 - Elsevier
Ferroptosis is a newly identified form of cell death characterized by accumulation of
intracellular iron and requirement of lipid peroxidation. However, whether arsenite triggers …

Intracellular behavior of Nocardia seriolae and its apoptotic effect on RAW264.7 macrophages

W Liu, Y Deng, A Tan, F Zhao, O Chang… - Frontiers in Cellular …, 2023 - frontiersin.org
Nocardia seriolae, an intracellular gram-positive pathogen, is prone to infecting
immunocompromised and surface-damaged fish, causing serious losses to the aquaculture …

Arsenite impinges on endoplasmic reticulum-mitochondria crosstalk to elicit mitochondrial ROS formation and downstream toxicity

O Cantoni, E Zito, M Fiorani, A Guidarelli - Seminars in cancer biology, 2021 - Elsevier
Arsenite is an important carcinogen and toxic compound, causing various deleterious effects
through multiple mechanisms. In this review, we focused on mitochondrial ROS (mitoROS) …

Mitochondrial oxidative stress is the general reason for apoptosis induced by different-valence heavy metals in cells and mitochondria

SM Korotkov - International Journal of Molecular Sciences, 2023 - mdpi.com
This review analyzes the causes and consequences of apoptosis resulting from oxidative
stress that occurs in mitochondria and cells exposed to the toxic effects of different-valence …

[HTML][HTML] Calcium signals between the ryanodine receptor-and mitochondria critically regulate the effects of arsenite on mitochondrial superoxide formation and on the …

A Guidarelli, M Fiorani, L Cerioni, O Cantoni - Redox biology, 2019 - Elsevier
A low concentration of arsenite (6 h), selectively stimulating the intraluminal crosstalk
between the inositol-1, 4, 5-triphosphate receptor and the ryanodine receptor (RyR) …

[HTML][HTML] Enhanced sciatic nerve regeneration by relieving iron-overloading and organelle stress with the nanofibrous P (MMD-co-LA)/DFO conduits

L Han, X Dong, T Qiu, Z Dou, L Wu, H Dai - Materials Today Bio, 2022 - Elsevier
Wallerian degeneration after peripheral nerve injury (PNI), that is, the autonomous
degeneration of distal axons, leads to an imbalance of iron homeostasis and easily induces …

Deferoxamine Promotes Peripheral Nerve Regeneration by Enhancing Schwann Cell Function and Promoting Axon Regeneration of Dorsal Root Ganglion

T Zhang, J Zhao, Y Guan, X Li, J Bai, X Song, Z Jia… - Neuroscience, 2023 - Elsevier
Deferoxamine (DFO) is a potent iron chelator for clinical treatment of various diseases.
Recent studies have also shown its potential to promote vascular regeneration during …