Histone dacetylases (HDACs) are a group of enzymes that remove acetyl groups from
histones and regulate expression of tumor suppressor genes. They are implicated in many …

The oceans are a uniquely rich source of bioactive metabolites, of which sponges have
been shown to be among the most prolific producers of diverse bioactive secondary …

The interest in histone deacetylase (HDACa) inhibitors began almost 30 years ago during
some studies designed to understand why dimethyl sulfoxide (DMSO) caused terminal …

Covering: 2006. Previous review: Nat. Prod. Rep., 2007, 24, 31 This review covers the
literature published in 2006 for marine natural products, with 758 citations (534 for the …

Histone Deacetylase (HDAC) inhibitors are a relatively new class of anti-cancer agents that
play important roles in epigenetic or non-epigenetic regulation, inducing death, apoptosis …

The efficient total synthesis of the recently described natural substance largazole (1) and its
active metabolite largazole thiol (2) is described. The synthesis required eight linear steps …

Cyclopeptides or cyclic peptides are polypeptides formed by ring closing of terminal amino
acids. A large number of natural cyclopeptides have been reported to be highly effective …

This review is an overview on marine bioactive peptides with promising activities for the
development of alternative drugs to fight human pathologies. In particular, we focus on …

Histone deacetylases (HDACs) are validated targets for anticancer therapy as attested by
the approval of suberoylanilide hydroxamic acid (SAHA) and romidepsin (FK228) for treating …

Marine sponges have been a prolific source of unique bioactive compounds that are
presumed to act as a deterrent to predation. Many of these compounds have potential …