Major depressive disorder (MDD) is a debilitating illness characterized by neuroanatomical
and functional alterations in limbic structures, notably the prefrontal cortex (PFC), that can be …

The nucleus accumbens is a major input structure of the basal ganglia and integrates
information from cortical and limbic structures to mediate goal-directed behaviors. Chronic …

Apart from having been used and misused for at least four millennia for, among others,
recreational and medicinal purposes, the cannabis plant and its most peculiar chemical …

Cannabidiol (CBD) is a non-psychotomimetic phytocannabinoid derived from Cannabis
sativa. It has possible therapeutic effects over a broad range of neuropsychiatric disorders …

The CB 1 and CB 2 cannabinoid receptors (CB 1 R, CB 2 R) are members of the G protein-
coupled receptor (GPCR) family that were identified over 20 years ago. CB 1 Rs and CB 2 …

There are at least two types of cannabinoid receptors (CB1 and CB2). Ligands activating
these G protein-coupled receptors (GPCRs) include the phytocannabinoid Δ9 …

Cannabis sativa is the source of a unique set of compounds known collectively as plant
cannabinoids or phytocannabinoids. This review focuses on the manner with which three of …

Aims Recently, several synthetic cannabinoids were identified in herbal mixtures consumed
as recreational drugs alternative to cannabis products. The aim was to characterize the …

Alzheimer's disease (AD) is a neurodegenerative disease, in which the primary etiology
remains unknown. AD presents amyloid beta (Aβ) protein aggregation and neurofibrillary …

The last decades have seen a major gain in understanding the action of cannabinoids and
the endocannabinoid system in reward processing and the development of addictive …