Composition, structure and mechanical properties define performance of pulmonary surfactant membranes and films

E Parra, J Pérez-Gil - Chemistry and physics of lipids, 2015 - Elsevier
The respiratory surface in the mammalian lung is stabilized by pulmonary surfactant, a
membrane-based system composed of multiple lipids and specific proteins, the primary …

[HTML][HTML] Structure-function relationships in pulmonary surfactant membranes: from biophysics to therapy

E Lopez-Rodriguez, J Pérez-Gil - Biochimica et Biophysica Acta (BBA) …, 2014 - Elsevier
Pulmonary surfactant is an essential lipid–protein complex to maintain an operative
respiratory surface at the mammalian lungs. It reduces surface tension at the alveolar air …

[HTML][HTML] Structure of pulmonary surfactant membranes and films: the role of proteins and lipid–protein interactions

J Pérez-Gil - Biochimica et Biophysica Acta (BBA)-Biomembranes, 2008 - Elsevier
The pulmonary surfactant system constitutes an excellent example of how dynamic
membrane polymorphism governs some biological functions through specific lipid–lipid …

Cholesterol rules: direct observation of the coexistence of two fluid phases in native pulmonary surfactant membranes at physiological temperatures

JB de la Serna, J Perez-Gil, AC Simonsen… - Journal of Biological …, 2004 - ASBMB
Pulmonary surfactant, the lipid-protein material that stabilizes the respiratory surface of the
lungs, contains approximately equimolar amounts of saturated and unsaturated …

Pulmonary surfactant metabolism in the alveolar airspace: Biogenesis, extracellular conversions, recycling

B Olmeda, M Martínez-Calle, J Pérez-Gil - Annals of Anatomy …, 2017 - Elsevier
Pulmonary surfactant is a lipid–protein complex that lines and stabilizes the respiratory
interface in the alveoli, allowing for gas exchange during the breathing cycle. At the same …

Interfacial properties of pulmonary surfactant layers

R Wüstneck, J Perez-Gil, N Wüstneck, A Cruz… - Advances in colloid and …, 2005 - Elsevier
The composition of the pulmonary surfactant and the border conditions of normal human
breathing are relevant to characterize the interfacial behavior of pulmonary layers. Based on …

Comparative transcriptome analyses indicate molecular homology of zebrafish swimbladder and mammalian lung

W Zheng, Z Wang, JE Collins, RM Andrews, D Stemple… - PloS one, 2011 - journals.plos.org
The fish swimbladder is a unique organ in vertebrate evolution and it functions for regulating
buoyancy in most teleost species. It has long been postulated as a homolog of the tetrapod …

Special relationship between sterols and oxygen: were sterols an adaptation to aerobic life?

AM Galea, AJ Brown - Free Radical Biology and Medicine, 2009 - Elsevier
A fascinating link between sterols and molecular oxygen (O2) has been a common thread
running through the fundamental work of Konrad Bloch, who elucidated the biosynthetic …

A central theory of biology

JS Torday - Medical hypotheses, 2015 - Elsevier
The history of physiologic cellular–molecular interrelationships can be traced all the way
back to the unicellular state by following the pathway formed by lipids ubiquitously …

The lipid composition of autophagic vacuoles regulates expression of multilamellar bodies

P Lajoie, G Guay, JW Dennis… - Journal of cell …, 2005 - journals.biologists.com
Multilamellar bodies (MLBs) are responsible for surfactant secretion in type II alveolar cells
but also accumulate in other cell types under pathological conditions, including cancer and …