The neural crest (NC) is a transient, multipotent and migratory cell population that generates
an astonishingly diverse array of cell types during vertebrate development. These cells …

The progressive loss of pancreatic β‐cell mass that occurs in both type 1 and type 2
diabetes is a primary factor driving efforts to identify strategies for effectively increasing …

The developing pancreatic epithelium gives rise to all endocrine and exocrine cells of the
mature organ. During organogenesis, the epithelial cells receive essential signals from the …

Arising within the neural tube between the cranial and trunk regions of the body axis, the
vagal neural crest shares interesting similarities in its migratory routes and derivatives with …

Neurovascular alignment is a common anatomical feature of organs, but the mechanisms
leading to this arrangement are incompletely understood. Here, we show that vascular …

In 1998, the landmark paper describing the isolation and culture of human embryonic stem
cells (ESCs) was published. Since that time, the main goal of many diabetes researchers …

Nkx2. 2 and Arx are essential pancreatic transcription factors. Nkx2. 2 is necessary for the
appropriate specification of the islet alpha, beta, PP and epsilon cell lineages, whereas Arx …

Three-dimensional tissue-structural relationships are not well captured by typical thin-
section histology, posing challenges for the study of tissue physiology and pathology …

Type 2 diabetes, characterized by persistent hyperglycemia, arises mostly from beta cell
dysfunction and insulin resistance and remains a highly complex metabolic disease due to …

Pancreatic endocrine cells are produced from a dynamic epithelium in a process that, as in
any developing organ, is driven by interacting programs of spatiotemporally regulated …