Neural and psychological mechanisms underlying compulsive drug seeking habits and drug memories–indications for novel treatments of addiction

BJ Everitt - European Journal of Neuroscience, 2014 - Wiley Online Library
This review discusses the evidence for the hypothesis that the development of drug
addiction can be understood in terms of interactions between Pavlovian and instrumental …

Dissecting impulsivity and its relationships to drug addictions

JD Jentsch, JR Ashenhurst… - Annals of the New …, 2014 - Wiley Online Library
Addictions are often characterized as forms of impulsive behavior. That said, it is often noted
that impulsivity is a multidimensional construct, spanning several psychological domains …

Imaging addiction: D2 receptors and dopamine signaling in the striatum as biomarkers for impulsivity

P Trifilieff, D Martinez - Neuropharmacology, 2014 - Elsevier
Dependence to drugs of abuse is closely associated with impulsivity, or the propensity to
choose a lower, but immediate, reward over a delayed, but more valuable outcome. Here …

[HTML][HTML] Sensation-seeking: Dopaminergic modulation and risk for psychopathology

A Norbury, M Husain - Behavioural brain research, 2015 - Elsevier
Sensation-seeking (SS) is a personality trait that refers to individual differences in motivation
for intense and unusual sensory experiences. It describes a facet of human behaviour that …

Neural circuitry and mechanisms of waiting impulsivity: relevance to addiction

JW Dalley, KD Ersche - Philosophical Transactions of the …, 2019 - royalsocietypublishing.org
Impatience—the failure to wait or tolerate delayed rewards (eg food, drug and monetary
incentives)—is a common behavioural tendency in humans. However, when rigidly and …

Noradrenergic versus dopaminergic modulation of impulsivity, attention and monitoring behaviour in rats performing the stop-signal task: possible relevance to ADHD

A Bari, TW Robbins - Psychopharmacology, 2013 - Springer
Rationale Deficient response inhibition is a prominent feature of many pathological
conditions characterised by impulsive and compulsive behaviour. Clinically effective doses …

Behavioral endophenotypes of drug addiction: etiological insights from neuroimaging studies

B Jupp, JW Dalley - Neuropharmacology, 2014 - Elsevier
This article reviews recent advances in the elucidation of neurobehavioral endophenotypes
associated with drug addiction made possible by the translational neuroimaging techniques …

Oscillatory activity in the medial prefrontal cortex and nucleus accumbens correlates with impulsivity and reward outcome

NA Donnelly, T Holtzman, PD Rich… - PloS one, 2014 - journals.plos.org
Actions expressed prematurely without regard for their consequences are considered
impulsive. Such behaviour is governed by a network of brain regions including the prefrontal …

Brain and cognition for addiction medicine: From prevention to recovery neural substrates for treatment of psychostimulant-induced cognitive deficits

MS D'Souza - Frontiers in psychiatry, 2019 - frontiersin.org
Addiction to psychostimulants like cocaine, methamphetamine, and nicotine poses a
continuing medical and social challenge both in the United States and all over the world …

[HTML][HTML] Dissociable rate-dependent effects of oral methylphenidate on impulsivity and D2/3 receptor availability in the striatum

D Caprioli, B Jupp, YT Hong, SJ Sawiak… - Journal of …, 2015 - Soc Neuroscience
We have previously shown that impulsivity in rats is linked to decreased dopamine D 2/3
receptor availability in the ventral striatum. In the present study, we investigated, using …