Therapeutics targeting the IL-23 and IL-17 pathway in psoriasis

K Ghoreschi, A Balato, C Enerbäck, R Sabat - The Lancet, 2021 - thelancet.com
Psoriasis is a chronic inflammatory disease characterised by sharply demarcated
erythematous and scaly skin lesions accompanied by systemic manifestations. Classified by …

Pathophysiology, clinical presentation, and treatment of psoriasis: a review

AW Armstrong, C Read - Jama, 2020 - jamanetwork.com
Importance Approximately 125 million people worldwide have psoriasis. Patients with
psoriasis experience substantial morbidity and increased rates of inflammatory arthritis …

Systemic pharmacological treatments for chronic plaque psoriasis: a network meta‐analysis

E Sbidian, A Chaimani, R Guelimi… - Cochrane Database …, 2023 - cochranelibrary.com
Background Psoriasis is an immune‐mediated disease with either skin or joints
manifestations, or both, and it has a major impact on quality of life. Although there is …

[HTML][HTML] Challenges and future trends in the treatment of psoriasis

HJ Lee, M Kim - International Journal of Molecular Sciences, 2023 - mdpi.com
Psoriasis is a chronic inflammatory skin disorder, and current treatments include topical
therapies, phototherapy, systemic immune modulators, and biologics, aiming to alleviate …

An Oral Interleukin-23–Receptor Antagonist Peptide for Plaque Psoriasis

R Bissonnette, A Pinter, LK Ferris… - … England Journal of …, 2024 - Mass Medical Soc
Background The use of monoclonal antibodies has changed the treatment of several
immune-mediated inflammatory diseases, including psoriasis. However, these large …

Biologics‐loaded photothermally dissolvable hyaluronic acid microneedle patch for psoriasis treatment

D Wu, X Shou, Y Yu, X Wang, G Chen… - Advanced Functional …, 2022 - Wiley Online Library
Emerging biologics, such as monoclonal antibodies (mAbs), are the most promising
treatment for psoriasis, while their effective delivery to the local inflammatory area of the skin …

Disease modification in inflammatory skin disorders: opportunities and challenges

T Bieber - Nature Reviews Drug Discovery, 2023 - nature.com
Progress in understanding of the mechanisms underlying chronic inflammatory skin
disorders, such as atopic dermatitis and psoriasis vulgaris, has led to new treatment options …

Risankizumab treatment in psoriasis patients who failed anti‐IL17: a 52‐week real‐life study

M Megna, L Potestio, A Ruggiero… - Dermatologic …, 2022 - Wiley Online Library
Recent knowledge on the key role of interleukin (IL) 23/17 axis in psoriasis pathogenesis,
led to development of new biologic drugs. Risankizumab is a humanized immunoglobulin …

[HTML][HTML] From empirical to pathogenesis-based treatments for psoriasis

PCM van de Kerkhof - Journal of Investigative Dermatology, 2022 - Elsevier
Since the foundation of the European Society for Dermatological Research, pathogenesis of
psoriasis has been studied by many research groups, focusing on various compartments of …

Microneedles as a momentous platform for psoriasis therapy and diagnosis: A state-of-the-art review

BHJ Gowda, MG Ahmed, U Hani, P Kesharwani… - International Journal of …, 2023 - Elsevier
Psoriasis is a chronic, autoimmune, and non-communicable skin disease with a worldwide
prevalence rate of 2–3%, creating an economic burden on global health. Some significant …