Background Effects of major dietary macronutrients on glucose-insulin homeostasis remain
controversial and may vary by the clinical measures examined. We aimed to assess how …

Insulin resistance condition is associated to the development of several syndromes, such as
obesity, type 2 diabetes mellitus and metabolic syndrome. Although the factors linking …

Membrane uptake of long-chain fatty acids (FAs) is the first step in cellular FA utilization and
a point of metabolic regulation. CD36 facilitates a major fraction of FA uptake by key tissues …

Conclusion Both frailty and sarcopenia are common occurrences in persons older than 55
years with diabetes (Figure 3). They are highly correlated with poor outcomes and are …

Aims/hypothesis Although the substitution of saturated fatty acids with oleate has been
recommended in the management of type 2 diabetes mellitus, the mechanisms by which …

Increased plasma levels of free fatty acids (FFA) occur in states of insulin resistance such as
obesity and type 2 diabetes mellitus. These high levels of plasma FFA are proposed to play …

Obesity is characterized by adipose tissue expansion as well as macrophage infiltration of
adipose tissue. This results in an increase in circulating inflammatory cytokines and …

Insulin-resistance is a characteristic feature of type 2 diabetes (T2D) and plays a major role
in the pathogenesis of this disease. Skeletal muscles are quantitatively the biggest glucose …

Aging is associated with alterations in glucose metabolism and sarcopenia that jointly
contribute to a higher risk of developing type 2 diabetes. Because aging is considered as a …

Recent studies have linked obesity, type 2 diabetes mellitus (T2DM) or non-alcoholic
steatohepatitis (NASH) to insulin resistance in the brain, cognitive impairment and …