Effects of saturated fat, polyunsaturated fat, monounsaturated fat, and carbohydrate on glucose-insulin homeostasis: a systematic review and meta-analysis of …
Background Effects of major dietary macronutrients on glucose-insulin homeostasis remain
controversial and may vary by the clinical measures examined. We aimed to assess how …
controversial and may vary by the clinical measures examined. We aimed to assess how …
Mechanisms underlying skeletal muscle insulin resistance induced by fatty acids: importance of the mitochondrial function
Insulin resistance condition is associated to the development of several syndromes, such as
obesity, type 2 diabetes mellitus and metabolic syndrome. Although the factors linking …
obesity, type 2 diabetes mellitus and metabolic syndrome. Although the factors linking …
Cellular fatty acid uptake: a pathway under construction
X Su, NA Abumrad - Trends in Endocrinology & Metabolism, 2009 - cell.com
Membrane uptake of long-chain fatty acids (FAs) is the first step in cellular FA utilization and
a point of metabolic regulation. CD36 facilitates a major fraction of FA uptake by key tissues …
a point of metabolic regulation. CD36 facilitates a major fraction of FA uptake by key tissues …
Frailty, sarcopenia and diabetes
JE Morley, TK Malmstrom, L Rodriguez-Mañas… - Journal of the American …, 2014 - jamda.com
Conclusion Both frailty and sarcopenia are common occurrences in persons older than 55
years with diabetes (Figure 3). They are highly correlated with poor outcomes and are …
years with diabetes (Figure 3). They are highly correlated with poor outcomes and are …
Oleate prevents saturated-fatty-acid-induced ER stress, inflammation and insulin resistance in skeletal muscle cells through an AMPK-dependent mechanism
L Salvadó, T Coll, AM Gómez-Foix, E Salmeron… - Diabetologia, 2013 - Springer
Aims/hypothesis Although the substitution of saturated fatty acids with oleate has been
recommended in the management of type 2 diabetes mellitus, the mechanisms by which …
recommended in the management of type 2 diabetes mellitus, the mechanisms by which …
Saturated fatty acid‐induced insulin resistance is associated with mitochondrial dysfunction in skeletal muscle cells
Increased plasma levels of free fatty acids (FFA) occur in states of insulin resistance such as
obesity and type 2 diabetes mellitus. These high levels of plasma FFA are proposed to play …
obesity and type 2 diabetes mellitus. These high levels of plasma FFA are proposed to play …
Muscle inflammatory response and insulin resistance: synergistic interaction between macrophages and fatty acids leads to impaired insulin action
V Varma, A Yao-Borengasser… - American Journal …, 2009 - journals.physiology.org
Obesity is characterized by adipose tissue expansion as well as macrophage infiltration of
adipose tissue. This results in an increase in circulating inflammatory cytokines and …
adipose tissue. This results in an increase in circulating inflammatory cytokines and …
Sphingolipid metabolism: new insight into ceramide-induced lipotoxicity in muscle cells
CL Bandet, S Tan-Chen, O Bourron, H Le Stunff… - International journal of …, 2019 - mdpi.com
Insulin-resistance is a characteristic feature of type 2 diabetes (T2D) and plays a major role
in the pathogenesis of this disease. Skeletal muscles are quantitatively the biggest glucose …
in the pathogenesis of this disease. Skeletal muscles are quantitatively the biggest glucose …
Elevated muscle TLR4 expression and metabolic endotoxemia in human aging
S Ghosh, R Lertwattanarak, JJ Garduño… - … Series A: Biomedical …, 2015 - academic.oup.com
Aging is associated with alterations in glucose metabolism and sarcopenia that jointly
contribute to a higher risk of developing type 2 diabetes. Because aging is considered as a …
contribute to a higher risk of developing type 2 diabetes. Because aging is considered as a …
[HTML][HTML] Insulin resistance and neurodegeneration: roles of obesity, type 2 diabetes mellitus and non-alcoholic steatohepatitis
SM de la Monte, L Longato, M Tong… - Current opinion in …, 2009 - ncbi.nlm.nih.gov
Recent studies have linked obesity, type 2 diabetes mellitus (T2DM) or non-alcoholic
steatohepatitis (NASH) to insulin resistance in the brain, cognitive impairment and …
steatohepatitis (NASH) to insulin resistance in the brain, cognitive impairment and …